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Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel\n                    <jats:italic>et al.<\/jats:italic>\n                    show that when intestinal epithelial cells sense an invading bacterial pathogen, they \u201creroute\u201d the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6355\" page=\"1047\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126\/science.aal4677\">1047<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6355\" page=\"976\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126\/science.aao4158\">976<\/jats:related-article>\n                  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