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Research leading to effective treatments has been hampered by a lack of informative animal models. Ho\n            <jats:italic>et al.<\/jats:italic>\n            identified ELABELA as a hormone produced by the placenta whose levels are lower in preeclampsia (see the Perspective by Wirka and Quertermous). ELABELA-deficient pregnant mice showed clinical signs of preeclampsia, including high blood pressure and elevated urine protein. A proportion of embryos lacking ELABELA displayed defective heart development, and full-term pups had low birth weights.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6352\" page=\"707\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126\/science.aam6607\">707<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6352\" page=\"643\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126\/science.aao2642\">643<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aam6607","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T01:10:31Z","timestamp":1498785031000},"page":"707-713","source":"Crossref","is-referenced-by-count":202,"title":["ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice"],"prefix":"10.1126","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-3154","authenticated-orcid":false,"given":"Lena","family":"Ho","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-3441","authenticated-orcid":false,"given":"Marie","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Reproductive Biology Laboratory, Obstetrics and Gynaecology, Academic Medical Center (AMC), Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-4112","authenticated-orcid":false,"given":"Sam Tan Jian","family":"Chye","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Messerschmidt","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-8792","authenticated-orcid":false,"given":"Serene C.","family":"Chng","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-7944","authenticated-orcid":false,"given":"Sheena","family":"Ong","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-139X","authenticated-orcid":false,"given":"Ling Ka","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souad","family":"Boussata","sequence":"additional","affiliation":[{"name":"Reproductive Biology Laboratory, Obstetrics and Gynaecology, Academic Medical Center (AMC), Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-9939","authenticated-orcid":false,"given":"Grace Hui-Yi","family":"Goh","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-725X","authenticated-orcid":false,"given":"Gijs B.","family":"Afink","sequence":"additional","affiliation":[{"name":"Reproductive Biology Laboratory, Obstetrics and Gynaecology, Academic Medical Center (AMC), Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-002X","authenticated-orcid":false,"given":"Chin Yan","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, A*STAR, 8A Biomedical Grove, Immunos, Singapore 138648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-2975","authenticated-orcid":false,"given":"N. 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