{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:37:34Z","timestamp":1791380254687,"version":"4.3.3"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6365","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.31770190, and No. 81661148054, No.81661130162, No.81522025, No.81621005"],"award-info":[{"award-number":["No.31770190, and No. 81661148054, No.81661130162, No.81522025, No.81621005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31730108"],"award-info":[{"award-number":["31730108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The National Key Research and Development Project of China","award":["No.2016YFD0500304"],"award-info":[{"award-number":["No.2016YFD0500304"]}]},{"name":"the National Science and Technology Major Project of China","award":["No.2017ZX09101005 and No.2017ZX10304402"],"award-info":[{"award-number":["No.2017ZX09101005 and No.2017ZX10304402"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2017,11,17]]},"abstract":"<jats:title>Mutation for microcephaly<\/jats:title>\n                  <jats:p>\n                    Zika virus infections in humans have been known since 1947. Microcephaly and neuropathologies associated with Zika have only been reported recently, most prevalently in the Americas. Yuan\n                    <jats:italic>et al.<\/jats:italic>\n                    investigated recent stable mutations in the virus genome and engineered them into a low-virulence ancestral strain (see the Perspective by Screaton and Mongkolsapaya). A single amino acid substitution (serine to asparagine, S139N) in the viral precursor membrane protein exacerbated symptoms in pregnant mice. The reverse mutation (N139S) was less virulent. The S139N mutation arose in 2013 in French Polynesia before the virus jumped to Brazil in 2015. In vitro, this amino acid change made the virus more infectious for mouse and human neural progenitor cells and promoted apoptosis. The terrible sequelae of infection during pregnancy could thus be the result of a simple viral mutation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6365\" page=\"933\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aam7120\">933<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6365\" page=\"863\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aaq1297\">863<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aam7120","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T20:24:28Z","timestamp":1506716668000},"page":"933-936","source":"Crossref","is-referenced-by-count":469,"title":["A single mutation in the prM protein of Zika virus contributes to fetal microcephaly"],"prefix":"10.1126","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-5097","authenticated-orcid":true,"given":"Ling","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, CAS, Beijing 100101, China."},{"name":"University of CAS, Beijing 100101, 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