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However, their inappropriate release may do more harm than good by promoting inflammation and thrombosis. Jim\u00e9nez-Alc\u00e1zar\n                    <jats:italic>et al.<\/jats:italic>\n                    report that two deoxyribonucleases (DNases), DNASE1 and DNASE1L3, have partially redundant roles in degrading NETs in the circulation (see the Perspective by Gunzer). Knockout mice lacking these enzymes were unable to tolerate chronic neutrophilia, quickly dying after blood vessels were occluded by NET clots. Furthermore, the damage unleashed by clots during septicemia was enhanced when these DNases were absent.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6367\" page=\"1202\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aam8897\">1202<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6367\" page=\"1126\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aar2428\">1126<\/jats:related-article>\n                  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