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Mice that are trisomic for the sex chromosomes are infertile. Hirota\n                    <jats:italic>et al.<\/jats:italic>\n                    demonstrate that reprogramming cells from sterile mice with chromosome trisomies XXY or XYY generates XY stem cells. Sperm generated from these XY stem cells could give rise to healthy, fertile offspring. Reprogramming also promoted loss of the extra chromosome in cells from patients with Klinefelter (XXY) or Down (trisomy 21) syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6354\" page=\"932\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126\/science.aam9046\">932<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aam9046","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T20:50:23Z","timestamp":1503003023000},"page":"932-935","source":"Crossref","is-referenced-by-count":56,"title":["Fertile offspring from sterile sex chromosome trisomic mice"],"prefix":"10.1126","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-3225","authenticated-orcid":false,"given":"Takayuki","family":"Hirota","sequence":"first","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan."},{"name":"Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO), Kyoto, 606-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-8262","authenticated-orcid":false,"given":"Benjamin E.","family":"Powell","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-0844","authenticated-orcid":false,"given":"Shantha K.","family":"Mahadevaiah","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obah A.","family":"Ojarikre","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6798","authenticated-orcid":false,"given":"Mitinori","family":"Saitou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan."},{"name":"Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO), Kyoto, 606-8501, Japan."},{"name":"Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan."},{"name":"Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, 606-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-7677","authenticated-orcid":false,"given":"James M. 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