{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:52:13Z","timestamp":1790232733846,"version":"4.1.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6362","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["award304792"],"award-info":[{"award-number":["award304792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R56 AI117675"],"award-info":[{"award-number":["1R56 AI117675"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["award348894"],"award-info":[{"award-number":["award348894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56 AI127371"],"award-info":[{"award-number":["R56 AI127371"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2017,10,27]]},"abstract":"<jats:title>Broadly reactive drugs for flu<\/jats:title>\n                  <jats:p>\n                    Drugs for influenza are limited. For those available, viral resistance is rife. Part of the problem is that the virus is constantly mutating. Kadam\n                    <jats:italic>et al.<\/jats:italic>\n                    tested the cell entry stage of the virus life cycle as a drug target (see the Perspective by Whitehead). Cell entry is mediated by the major surface glycoprotein hemagglutinin (HA). This stage can be blocked by broadly neutralizing antibodies binding to HA. The authors generated small cyclic peptides that bind to the same sites on HA as the antibodies and mimic their activity. The peptides are cheap and easy to synthesize, are nontoxic to mice, and prevented infection of cells by many types of influenza virus.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6362\" page=\"496\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aan0516\">496<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6362\" page=\"450\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aap9608\">450<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aan0516","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T20:24:28Z","timestamp":1506716668000},"page":"496-502","source":"Crossref","is-referenced-by-count":162,"title":["Potent peptidic fusion inhibitors of influenza virus"],"prefix":"10.1126","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-9250","authenticated-orcid":false,"given":"Rameshwar U.","family":"Kadam","sequence":"first","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7430-2771","authenticated-orcid":false,"given":"Jarek","family":"Juraszek","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-3802","authenticated-orcid":false,"given":"Boerries","family":"Brandenburg","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-1161","authenticated-orcid":false,"given":"Christophe","family":"Buyck","sequence":"additional","affiliation":[{"name":"Discovery Sciences, Janssen Research &amp; Development, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-6773","authenticated-orcid":false,"given":"Wim B. G.","family":"Schepens","sequence":"additional","affiliation":[{"name":"Discovery Sciences, Janssen Research &amp; Development, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-4153","authenticated-orcid":false,"given":"Bart","family":"Kesteleyn","sequence":"additional","affiliation":[{"name":"Janssen Infectious Diseases and Vaccines, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-2696","authenticated-orcid":false,"given":"Bart","family":"Stoops","sequence":"additional","affiliation":[{"name":"Discovery Sciences, Janssen Research &amp; Development, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-1371","authenticated-orcid":false,"given":"Rob J.","family":"Vreeken","sequence":"additional","affiliation":[{"name":"Discovery Sciences, Janssen Research &amp; Development, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-8912","authenticated-orcid":false,"given":"Jan","family":"Vermond","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-5504","authenticated-orcid":false,"given":"Wouter","family":"Goutier","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-4116","authenticated-orcid":false,"given":"Chan","family":"Tang","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Vogels","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H. E.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Goudsmit","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-2402","authenticated-orcid":false,"given":"Maria J. P.","family":"van Dongen","sequence":"additional","affiliation":[{"name":"Janssen Prevention Center, Leiden, Netherlands."},{"name":"Discovery Sciences, Janssen Research &amp; Development, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-2419","authenticated-orcid":false,"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA."},{"name":"The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1779"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2175"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0900648"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.531"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/289366a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/371037a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2014_413"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222908"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202617"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2214"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005409"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12055"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.08.057"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01131-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)67772-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.10.4374"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171491"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1566"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000990"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205669"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00178-14"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.06.004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.033910.107"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.04.040"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617020114"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080034"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093373"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11414"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2272-7_13"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12424"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski Z.","year":"1977","unstructured":"Z. Otwinowski, W. Minor, Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276A, 307\u2013326 (1977).","journal-title":"Methods Enzymol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444905001617"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902016657"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889883010985"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aan0516","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aan0516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T11:40:06Z","timestamp":1705318806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aan0516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":39,"journal-issue":{"issue":"6362","published-print":{"date-parts":[[2017,10,27]]}},"alternative-id":["10.1126\/science.aan0516"],"URL":"https:\/\/doi.org\/10.1126\/science.aan0516","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731685027.793538263","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.731685027.793540094","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}