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However, it turns out that some of these subjects are part of the placebo group and thus never received any active medication. This is a case of the nocebo effect seriously interfering with medical treatment. Tinnermann\n            <jats:italic>et al.<\/jats:italic>\n            investigated whether value information such as the price of a medication can further modulate behavioral nocebo effects and the underlying neural network dynamics (see the Perspective by Colloca). They used brain imaging to characterize the circuits involved in nocebo hyperalgesia within the descending pain pathway from the prefrontal cortex to the spinal cord. Their findings revealed how value information increased the nocebo effect.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6359\" page=\"105\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aan1221\">105<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6359\" page=\"44\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aap8488\">44<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aan1221","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T17:55:31Z","timestamp":1507226131000},"page":"105-108","source":"Crossref","is-referenced-by-count":202,"title":["Interactions 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