{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:24:41Z","timestamp":1793157881087,"version":"4.5.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6371","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,1,5]]},"abstract":"Good bacteria help fight cancer<\/jats:title>\n \n Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy\n et al.<\/jats:italic>\n show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium\n Akkermansia muciniphila<\/jats:italic>\n . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson\n et al.<\/jats:italic>\n and Gopalakrishnan\n et al.<\/jats:italic>\n studied melanoma patients receiving PD-1 blockade and found a greater abundance of \u201cgood\u201d bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 91<\/jats:related-article>\n , p.\n 104<\/jats:related-article>\n , p.\n 97<\/jats:related-article>\n ; see also p.\n 32<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.aan3706","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T14:12:28Z","timestamp":1509631948000},"page":"91-97","source":"Crossref","is-referenced-by-count":5339,"title":["Gut microbiome influences efficacy of PD-1\u2013based immunotherapy against epithelial tumors"],"prefix":"10.1126","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-6571","authenticated-orcid":false,"given":"Bertrand","family":"Routy","sequence":"first","affiliation":[{"name":"Gustave Roussy Cancer Campus (GRCC), Villejuif, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche Medicale (INSERM) U1015 and Equipe Labellis\u00e9e\u2013Ligue Nationale contre le Cancer, Villejuif, France."},{"name":"Univ. 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