{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:56:44Z","timestamp":1790506604526,"version":"4.1.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6400","funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["702566"],"award-info":[{"award-number":["702566"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-142259"],"award-info":[{"award-number":["MOP-142259"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-156397"],"award-info":[{"award-number":["PJT-156397"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,7,27]]},"abstract":"<jats:title>Inflammation promotes gut polyposis<\/jats:title>\n                  <jats:p>\n                    Peutz\u2013Jeghers Syndrome (PJS) causes benign polyps in the gut and a higher risk of several cancers caused by mutations in the tumor suppressor gene\n                    <jats:italic>STK11<\/jats:italic>\n                    , which encodes liver kinase B1 (LKB1). LKB1's role in this disease is thought to be related to its tumor suppressor function. Now, Poffenberger\n                    <jats:italic>et al.<\/jats:italic>\n                    show that the T cell\u2013specific heterozygous deletion of\n                    <jats:italic>Stk11<\/jats:italic>\n                    is sufficient to reproduce PJS symptoms in mice (see the Perspective by Hollstein and Shaw). Polyps in mice and humans are characterized by immune cell infiltration, enhanced STAT3 signaling, and increased levels of inflammatory cytokines such as interleukin-6 (IL-6). Targeting STAT3 signaling, IL-6, or T cells ameliorated the polyps, suggesting potential therapies for this disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6400\" page=\"406\" related-article-type=\"in-this-issue\" vol=\"361\" xlink:href=\"10.1126\/science.aan3975\">406<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6400\" page=\"332\" related-article-type=\"in-this-issue\" vol=\"361\" xlink:href=\"10.1126\/science.aau4804\">332<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aan3975","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T14:06:11Z","timestamp":1532613971000},"page":"406-411","source":"Crossref","is-referenced-by-count":64,"title":["LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis"],"prefix":"10.1126","volume":"361","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-8853","authenticated-orcid":true,"given":"M. C.","family":"Poffenberger","sequence":"first","affiliation":[{"name":"Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada."},{"name":"Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-3765","authenticated-orcid":true,"given":"A.","family":"Metcalfe-Roach","sequence":"additional","affiliation":[{"name":"Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada."},{"name":"Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada."},{"name":"Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-3120","authenticated-orcid":true,"given":"B. 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