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Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell\n                    <jats:italic>et al.<\/jats:italic>\n                    systematically studied patterns of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6372\" page=\"191\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aan4472\">191<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6372\" page=\"159\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aar4189\">159<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aan4472","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T17:40:52Z","timestamp":1516124452000},"page":"191-199","source":"Crossref","is-referenced-by-count":273,"title":["Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics"],"prefix":"10.1126","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-6220","authenticated-orcid":true,"given":"Annie N.","family":"Cowell","sequence":"first","affiliation":[{"name":"School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-3248","authenticated-orcid":true,"given":"Eva S.","family":"Istvan","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-7643","authenticated-orcid":true,"given":"Amanda K.","family":"Lukens","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Harvard T.H. 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