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Kornberg\n                    <jats:italic>et al.<\/jats:italic>\n                    found that DMF and its metabolite, monomethyl fumarate, succinate the glycolytic enzyme GAPDH (see the Perspective by Matsushita and Pearce). After DMF treatment, GAPDH was inactivated, and aerobic glycolysis was down-regulated in both myeloid and lymphoid cells. This resulted in down-modulated immune responses because inflammatory immune-cell subsets require aerobic glycolysis. Thus, metabolism can serve as a viable therapeutic target in autoimmune disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6387\" page=\"449\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aan4665\">449<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6387\" page=\"377\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aat4984\">377<\/jats:related-article>\n                  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