{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:24:42Z","timestamp":1793413482207,"version":"4.5.0"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6406","funder":[{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2R01AG014713"],"award-info":[{"award-number":["2R01AG014713"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["1RF1AG048080"],"award-info":[{"award-number":["1RF1AG048080"]}]},{"DOI":"10.13039\/100007028","name":"The Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIA and NIMH","award":["5R01MH060009"],"award-info":[{"award-number":["5R01MH060009"]}]},{"name":"Mather\u2019s Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,9,7]]},"abstract":"<jats:title>Adult neurogenesis and Alzheimer's disease<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) pathology destroys neurons and synapses in the brain, leading to dementia. The brain generates new neurons throughout life in the hippocampus, a process called adult hippocampal neurogenesis (AHN). Choi\n                    <jats:italic>et al.<\/jats:italic>\n                    found that blocking AHN exacerbated cognitive impairment in an AD mouse model (see the Perspective by Spires-Jones and Ritchie). Inducing neurogenesis alone did not improve cognition in AD mice, whereas inducing neurogenesis while simultaneously ameliorating the neuronal environment via exercise did. The use of genetic or pharmacological treatments that simultaneously induced neurogenesis and increased levels of brain-derived neurotrophic factor (BDNF) mimicked the benefits of exercise on cognition. Thus, inducing both neurogenesis and providing BDNF may be useful as an AD therapeutic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aan8821\">eaan8821<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6406\" page=\"975\" related-article-type=\"in-this-issue\" vol=\"361\" xlink:href=\"10.1126\/science.aau8060\">975<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aan8821","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T14:06:35Z","timestamp":1536242795000},"source":"Crossref","is-referenced-by-count":750,"title":["Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer\u2019s mouse model"],"prefix":"10.1126","volume":"361","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-4380","authenticated-orcid":true,"given":"Se Hoon","family":"Choi","sequence":"first","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3533-0192","authenticated-orcid":true,"given":"Enjana","family":"Bylykbashi","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-6305","authenticated-orcid":true,"given":"Zena K.","family":"Chatila","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-7365","authenticated-orcid":true,"given":"Star W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-9897","authenticated-orcid":true,"given":"Benjamin","family":"Pulli","sequence":"additional","affiliation":[{"name":"Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-8112","authenticated-orcid":true,"given":"Gregory D.","family":"Clemenson","sequence":"additional","affiliation":[{"name":"Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-2848","authenticated-orcid":true,"given":"Eunhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rompala","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-2009","authenticated-orcid":true,"given":"Mary K.","family":"Oram","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-5247","authenticated-orcid":true,"given":"Caroline","family":"Asselin","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-8622","authenticated-orcid":true,"given":"Jenna","family":"Aronson","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-5118","authenticated-orcid":true,"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lesinski","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-0340","authenticated-orcid":true,"given":"Doo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-434X","authenticated-orcid":true,"given":"Henriette","family":"van Praag","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Spiegelman","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-4106","authenticated-orcid":true,"given":"Fred H.","family":"Gage","sequence":"additional","affiliation":[{"name":"Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-1454","authenticated-orcid":true,"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-85"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1305-10.2010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu155"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2634794100"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e318160c5db"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.033"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.015"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091531"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/6368"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04108"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173215"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00064"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2420"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1696"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005464"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240530408"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00066-X"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(03)00120-0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00084-X"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04539.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051272"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12298"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000218444.53405.f0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13800"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000612"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02143-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.011"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-008-8026-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.11.062"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.008"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.3.355"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03135.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100090"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02223.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.01.013"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283430a44"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.09.003"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00486.2002"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.015"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.033"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4715"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.033332.113"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20712"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005290"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1675"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.04.024"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep27812"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.07.033"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902960102"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aan8821","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aan8821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T12:38:12Z","timestamp":1705322292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aan8821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":55,"journal-issue":{"issue":"6406","published-print":{"date-parts":[[2018,9,7]]}},"alternative-id":["10.1126\/science.aan8821"],"URL":"https:\/\/doi.org\/10.1126\/science.aan8821","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"article-number":"eaan8821"}}