{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:51Z","timestamp":1790957871829,"version":"4.1.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6383","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA173750"],"award-info":[{"award-number":["R01 CA173750"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","award":["269516"],"award-info":[{"award-number":["269516"]}],"id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Prostate Cancer Foundation Young Investigator Award"},{"name":"Friends for Life Neuroblastoma Fellowship"},{"name":"A*STAR Graduate Fellowship"},{"name":"Cancer Research Institute\/Robertson Foundation"},{"name":"United States Deparment of Defense Fellowship","award":["DoD CA150776"],"award-info":[{"award-number":["DoD CA150776"]}]},{"name":"American Society of Clinical Oncology Young Investigator Award"},{"name":"NCI T32"},{"name":"Cancer Immunology Training Grant","award":["T32 CA207021"],"award-info":[{"award-number":["T32 CA207021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,3,30]]},"abstract":"<jats:title>Helping NK cells find their way<\/jats:title>\n                  <jats:p>\n                    MICA and MICB proteins can be expressed on tumors and act as \u201ckill me\u201d signals to the immune system. But tumors often disguise themselves by shedding these proteins, which prevents specialized natural killer (NK) cells from recognizing and destroying the cancer. Ferrari de Andrade\n                    <jats:italic>et al.<\/jats:italic>\n                    engineered antibodies directed against the site responsible for the proteolytic shedding of MICA and MICB (see the Perspective by Cerwenka and Lanier). The approach effectively locked MICA and MICB onto tumors so that NK cells could spot them for elimination. The antibodies exhibited preclinical efficacy in multiple tumor models, including humanized melanoma. Furthermore, the strategy reduced lung cancer metastasis after NK cell\u2013mediated tumor lysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6383\" page=\"1537\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aao0505\">1537<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6383\" page=\"1460\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aat2184\">1460<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aao0505","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T14:11:09Z","timestamp":1522332669000},"page":"1537-1542","source":"Crossref","is-referenced-by-count":437,"title":["Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell\u2013driven tumor immunity"],"prefix":"10.1126","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-2271","authenticated-orcid":true,"given":"Lucas","family":"Ferrari de Andrade","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA."},{"name":"Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-9271","authenticated-orcid":true,"given":"Rong En","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Cancer 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75 Francis Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Cheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-091X","authenticated-orcid":true,"given":"F. 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