{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:03:32Z","timestamp":1791633812513,"version":"4.3.4"},"reference-count":85,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6364","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M014088\/1"],"award-info":[{"award-number":["BB\/M014088\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Investissement d\u2019Avenir","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2017,11,10]]},"abstract":"<jats:title>Wave upon wave of disease<\/jats:title>\n          <jats:p>\n            The cholera pathogen,\n            <jats:italic>Vibrio cholerae<\/jats:italic>\n            , is considered to be ubiquitous in water systems, making the design of eradication measures apparently fruitless. Nevertheless, local and global\n            <jats:italic>Vibrio<\/jats:italic>\n            populations remain distinct. Now, Weill\n            <jats:italic>et al.<\/jats:italic>\n            and Domman\n            <jats:italic>et al.<\/jats:italic>\n            show that a surprising diversity between continents has been established. Latin America and Africa bear different variants of cholera toxin with different transmission dynamics and ecological niches. The data are not consistent with the establishment of long-term reservoirs of pandemic cholera or with a relationship to climate events.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6364\" page=\"785\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aad5901\">785<\/jats:related-article>\n            , p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6364\" page=\"789\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aao2136\">789<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aao2136","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T18:51:00Z","timestamp":1510253460000},"page":"789-793","source":"Crossref","is-referenced-by-count":179,"title":["Integrated view of\n            <i>Vibrio cholerae<\/i>\n            in the Americas"],"prefix":"10.1126","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-9185","authenticated-orcid":true,"given":"Daryl","family":"Domman","sequence":"first","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Quilici","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 des Bact\u00e9ries Pathog\u00e8nes Ent\u00e9riques, Paris, 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-6163","authenticated-orcid":true,"given":"Matthew J.","family":"Dorman","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-6003","authenticated-orcid":true,"given":"Elisabeth","family":"Njamkepo","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 des Bact\u00e9ries Pathog\u00e8nes Ent\u00e9riques, Paris, 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Mutreja","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."},{"name":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge CB2 0SP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Mather","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."},{"name":"Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-4440","authenticated-orcid":true,"given":"Gabriella","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico, D.F., Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-4397","authenticated-orcid":true,"given":"Rosario","family":"Morales-Espinosa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico, D.F., Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-136X","authenticated-orcid":true,"given":"Patrick A. D.","family":"Grimont","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 Biodiversit\u00e9 des Bact\u00e9ries Pathog\u00e8nes Emergentes, Paris, 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-3813","authenticated-orcid":true,"given":"Marcial Leonardo","family":"Liz\u00e1rraga-Partida","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California, (CICESE), Ensenada, Baja California, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3549-1543","authenticated-orcid":true,"given":"Christiane","family":"Bouchier","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Plate-forme G\u00e9nomique (PF1), Paris, 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Aanensen","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-9507","authenticated-orcid":true,"given":"Pablo","family":"Kuri-Morales","sequence":"additional","affiliation":[{"name":"Subsecretar\u00eda de Prevenci\u00f3n y Promoci\u00f3n de la Salud, Secretar\u00eda de Salud, Ciudad de M\u00e9xico, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-365X","authenticated-orcid":true,"given":"Cheryl L.","family":"Tarr","sequence":"additional","affiliation":[{"name":"Enteric Diseases Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-965X","authenticated-orcid":true,"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."},{"name":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge CB2 0SP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-5958","authenticated-orcid":true,"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-0441","authenticated-orcid":true,"given":"Josefina","family":"Campos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas, ANLIS, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-0010","authenticated-orcid":true,"given":"Alejandro","family":"Cravioto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico, D.F., Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-5799","authenticated-orcid":true,"given":"Fran\u00e7ois-Xavier","family":"Weill","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."},{"name":"Institut Pasteur, Unit\u00e9 des Bact\u00e9ries Pathog\u00e8nes Ent\u00e9riques, Paris, 75015, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-8505","authenticated-orcid":true,"given":"Nicholas R.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK."},{"name":"London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization Cholera ; www.who.int\/mediacentre\/factsheets\/fs107\/en\/."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00256"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2025"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.757-770.2002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002073020601"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-2452(99)80002-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00398-13"},{"key":"e_1_3_2_10_2","unstructured":"Pan American Health Organization\/World Health Organization Cholera in the Americas - Situation summary. Epidemiol. Update Cholera (2017); www.paho.org\/hq\/index.php?option=com_docman&task=doc_download&Itemid=270&gid=38251&lang=fr."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.7.1685-1690.1994"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00720-08"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.9.2474-2482.1993"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.1.173"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.5.1151-1156.1997"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5901"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.16.1.129-134.1982"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.124-134.2003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.1.114-118.1995"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00866-10"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00189-12"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169324"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90894-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.3.581-590.1999"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.3.621"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10392"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323408111"},{"key":"e_1_3_2_29_2","first-page":"419","article-title":"Epidemic cholera in Latin America: Spread and routes of transmission","volume":"98","author":"Guthmann J. P.","year":"1995","unstructured":"J. P. Guthmann, Epidemic cholera in Latin America: Spread and routes of transmission. J. Trop. Med. Hyg. 98, 419\u2013427 (1995). 8544225","journal-title":"J. Trop. Med. Hyg."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012928"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00157-11"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1711.110827"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/currents.outbreaks.c04478c7fbd9854ef6ba923cc81eb799"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01123-14"},{"key":"e_1_3_2_35_2","first-page":"1","article-title":"Food as a vehicle of transmission of cholera","volume":"17","author":"Rabbani G. H.","year":"1999","unstructured":"G. H. Rabbani, W. B. Greenough 3rd, Food as a vehicle of transmission of cholera. J. Diarrhoeal Dis. Res. 17, 1\u20139 (1999). 10892490","journal-title":"J. Diarrhoeal Dis. Res."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.18"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.62.513"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02160-15"},{"key":"e_1_3_2_39_2","unstructured":"World Health Organzation Prevention and control of cholera outbreaks: WHO policy and recommendations; www.who.int\/cholera\/technical\/prevention\/control\/en\/index1.html."},{"key":"e_1_3_2_40_2","unstructured":"Centers for Disease Control and Prevention Cholera ( Vibrio cholerae O1\/O139). 1996 Case Definition; https:\/\/wwwn.cdc.gov\/nndss\/conditions\/cholera\/case-definition\/1996\/."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182395"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1196"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv421"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp348"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000056"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12628"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw290"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew007"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syv068"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss075"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst028"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","unstructured":"M. Hunt et al . ARIBA: Rapid antimicrobial resistance genotyping directly from sequencing reads. bioRxiv 118000 [preprint] (2017). https:\/\/doi.org\/10.1101\/118000.","DOI":"10.1101\/118000"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00040-10"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01356-14"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800052341"},{"key":"e_1_3_2_63_2","unstructured":"S. G. Fraga thesis Universidad de Buenos Aires (2010)."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.10.2715-2722.1995"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep03710"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(90)90059-Y"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-46-7-611"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004053"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005072"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-173"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207359109"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01721-14"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907787106"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074829"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2001.130428"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1711.110794"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002981"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-154"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evv193"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120181"},{"key":"e_1_3_2_81_2","unstructured":"S. Yahyai thesis University of Maryland (2013)."},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2011.08.003"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05643-11"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086264"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36115"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/35020000"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608732113"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aao2136","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aao2136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T16:14:50Z","timestamp":1705335290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aao2136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":85,"journal-issue":{"issue":"6364","published-print":{"date-parts":[[2017,11,10]]}},"alternative-id":["10.1126\/science.aao2136"],"URL":"https:\/\/doi.org\/10.1126\/science.aao2136","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]}}}