{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:48:38Z","timestamp":1789512518310,"version":"build-2803163510"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6368","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM077596"],"award-info":[{"award-number":["GM077596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM008313"],"award-info":[{"award-number":["GM008313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2017,12,8]]},"abstract":"<jats:title>A source of methane in the upper ocean<\/jats:title>\n          <jats:p>\n            Methane concentrations are high in oxygenated surface waters. Methylphosphonate (MPn) is a suggested source, but an enzyme that synthesizes Mpn (MPnS) has so far only been identified in one ocean microbe, albeit an abundant one: the archaeon\n            <jats:italic>Nitrosopumilus maritimus<\/jats:italic>\n            . Born\n            <jats:italic>et al.<\/jats:italic>\n            describe the crystal structure of MPnS and of a related enzyme that acts on the same substrate but makes a different product. By comparing the structures, they determined sequence markers that allowed them to identify MPnS in other ocean microbes, including the abundant microbe\n            <jats:italic>Pelagibacter ubique<\/jats:italic>\n            . These findings support the proposal that MPn is a source of both methane and phosphorus in the upper aerobic ocean.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6368\" page=\"1336\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aao3435\">1336<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aao3435","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T18:50:43Z","timestamp":1512672643000},"page":"1336-1339","source":"Crossref","is-referenced-by-count":51,"title":["Structural basis for methylphosphonate biosynthesis"],"prefix":"10.1126","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-9022","authenticated-orcid":true,"given":"David A.","family":"Born","sequence":"first","affiliation":[{"name":"Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA."},{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-6615","authenticated-orcid":true,"given":"Emily C.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL, USA."},{"name":"Carl R. 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