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Bae\n                    <jats:italic>et al.<\/jats:italic>\n                    examined the genomes of single neurons from the prenatal developing human brain. Both the type of mutation and the rates of accumulation changed between gastrulation and neurogenesis. These early mutations could be generating useful neuronal diversity or could predispose individuals to later dysfunction. Lodato\n                    <jats:italic>et al.<\/jats:italic>\n                    also found that neurons take on somatic mutations as they age by sequencing single neurons from subjects aged 4 months to 82 years. Somatic mutations accumulated with increasing age and accumulated faster in individuals affected by inborn errors in DNA repair. Postmitotic mutations might only affect one neuron, but the accumulated divergence of genomes across the brain could affect function.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6375\" page=\"550\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aan8690\">550<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6375\" page=\"555\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aao4426\">555<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6375\" page=\"521\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aar6335\">521<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aao4426","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T14:05:30Z","timestamp":1512655530000},"page":"555-559","source":"Crossref","is-referenced-by-count":603,"title":["Aging and neurodegeneration are associated with increased mutations in single human neurons"],"prefix":"10.1126","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-1073","authenticated-orcid":false,"given":"Michael A.","family":"Lodato","sequence":"first","affiliation":[{"name":"Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children\u2019s Hospital, Boston, MA, USA."},{"name":"Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, 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