{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:37:01Z","timestamp":1790807821086,"version":"4.1.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6388","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["108008\/Z\/15\/Z"],"award-info":[{"award-number":["108008\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,5,4]]},"abstract":"<jats:title>\n                    Complement is a CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell metabolic rheostat\n                  <\/jats:title>\n                  <jats:p>\n                    Systemic lupus erythematosus (SLE) is associated with deficiencies in the complement protein C1q. Although C1q plays a role in the clearance of apoptotic cells, there are several redundant clearance pathways. Disruption of one pathway does not lead to an autoimmune defect. In a chronic graft-versus-host disease model of SLE, Ling\n                    <jats:italic>et al.<\/jats:italic>\n                    show that C1q dampens CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses to self-antigens. C1q modulates metabolism through the mitochondrial cell-surface protein p32\/gC1qR. The lack of C1q during a viral infection also enhances CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses. Thus, C1q plays a role as a \u201cmetabolic rheostat\u201d for effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6388\" page=\"558\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aao4555\">558<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aao4555","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T14:13:28Z","timestamp":1525356808000},"page":"558-563","source":"Crossref","is-referenced-by-count":195,"title":["C1q restrains autoimmunity and viral infection by regulating CD8\n                    <sup>+<\/sup>\n                    T cell metabolism"],"prefix":"10.1126","volume":"360","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-0005","authenticated-orcid":true,"given":"Guang Sheng","family":"Ling","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Imperial College London, London W12 ONN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-1661","authenticated-orcid":true,"given":"Greg","family":"Crawford","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Imperial College London, London W12 ONN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-5379","authenticated-orcid":true,"given":"Norzawani","family":"Buang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Imperial College London, London W12 ONN, 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