{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:57:19Z","timestamp":1792090639454,"version":"4.4.0"},"reference-count":64,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6380","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31330005"],"award-info":[{"award-number":["31330005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401141"],"award-info":[{"award-number":["81401141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370904"],"award-info":[{"award-number":["81370904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14YF1402200"],"award-info":[{"award-number":["14YF1402200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Projects of Shanghai Municipal Health Bureau Research Fund","award":["201440033"],"award-info":[{"award-number":["201440033"]}]},{"name":"Shanghai Jiao Tong University Research Funding on Medical and Engineering Interdisciplinary Projects","award":["YG2015ZD08"],"award-info":[{"award-number":["YG2015ZD08"]}]},{"name":"Songjiang District Health Bureau of Climbing Medical Program","award":["0702N14003"],"award-info":[{"award-number":["0702N14003"]}]},{"name":"Shanghai Shen Kang Hospital Development Center for chronic disease prevention and control project","award":["SHDC12015304"],"award-info":[{"award-number":["SHDC12015304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,3,9]]},"abstract":"<jats:title>Microbial modulation of diabetes<\/jats:title>\n                  <jats:p>\n                    Short-chain fatty acids (SCFAs) are produced by various human gut microbes. SCFAs act as an energy source to the colonic epithelium and are also sensed by host signaling pathways that modulate appetite and inflammation. Deficiency of gut SCFAs is associated with type 2 diabetes. Zhao\n                    <jats:italic>et al.<\/jats:italic>\n                    found that adopting a high-fiber diet promoted the growth of SCFA-producing organisms in diabetic humans. The high-fiber diet induced changes in the entire gut microbe community and correlated with elevated levels of glucagon-like peptide-1, a decline in acetylated hemoglobin levels, and improved blood-glucose regulation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6380\" page=\"1151\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aao5774\">1151<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aao5774","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T14:05:34Z","timestamp":1520517934000},"page":"1151-1156","source":"Crossref","is-referenced-by-count":2149,"title":["Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes"],"prefix":"10.1126","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-7140","authenticated-orcid":true,"given":"Liping","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."},{"name":"Department of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers University, NJ 08901, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-9728","authenticated-orcid":true,"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-8485","authenticated-orcid":true,"given":"Xiaoying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-1142","authenticated-orcid":true,"given":"Yan Y.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers University, NJ 08901, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhe","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilin","family":"Ma","sequence":"additional","affiliation":[{"name":"Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongying","family":"Ren","sequence":"additional","affiliation":[{"name":"Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Sijing Hospital of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Sijing Hospital of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Shen","sequence":"additional","affiliation":[{"name":"Sijing Hospital of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sijing Hospital of Songjiang District, Shanghai 201601, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qidong People\u2019s Hospital, Jiangsu 226200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qidong People\u2019s Hospital, Jiangsu 226200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-6780","authenticated-orcid":true,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-4922","authenticated-orcid":true,"given":"Yongde","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-892X","authenticated-orcid":true,"given":"Chenhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3089"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020125"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11450"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12198"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15766"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009085"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-11-39"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421903"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.195339"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665114001463"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02348-16"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.07.007"},{"key":"e_1_3_2_15_2","first-page":"447","article-title":"China guideline for type 2 diabetes (2013 edition)","volume":"6","author":"Chinese Diabetes Society","year":"2014","unstructured":"Chinese Diabetes Society, China guideline for type 2 diabetes (2013 edition). Chin. J. Diabetes Mellitus 6, 447\u2013498 (2014).","journal-title":"Chin. J. Diabetes Mellitus"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300287"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12506"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2939"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1178"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11319"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00889-14"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.02.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-014-9288-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28095"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27465"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-010-0206-6"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.01931.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.1.173"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.032"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00420"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(98)00025-8"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102830"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0025315400022736"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.22.110191.000555"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224203"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y.","year":"1995","unstructured":"Y. Benjamini, Y. Hochberg, Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 57, 289\u2013300 (1995).","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6977.446"},{"key":"e_1_3_2_38_2","unstructured":"Y. Yang G. Wang X. Pan China Food Composition (Book 1 Beijing Medical Univ. Press ed. 2 2009)."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)00743-8"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.01.072"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.07.156"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.10.153"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.08.024"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2008.00478.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859613000166"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.03.143"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02787-15"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr026"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts174"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq275"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp336"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.074492.107"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp278"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2575"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks479"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002358"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-119"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_3_2_64_2","first-page":"1384","article-title":"Exploring carbohydrate utilization capacity of Bifidobacterium pseudocatenulatum isolated from a morbidly obese child after dietary intervention","volume":"34","author":"Wu H.","year":"2015","unstructured":"H. Wu, R. Wang, Y. Zhao, X. Pang, J. Shen, C. Zhang, ., Exploring carbohydrate utilization capacity of Bifidobacterium pseudocatenulatum isolated from a morbidly obese child after dietary intervention. Genomics Appl. Biol. 34, 1384\u20131391 (2015).","journal-title":"Genomics Appl. Biol."},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2307"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aao5774","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aao5774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T17:57:43Z","timestamp":1719856663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aao5774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":64,"journal-issue":{"issue":"6380","published-print":{"date-parts":[[2018,3,9]]}},"alternative-id":["10.1126\/science.aao5774"],"URL":"https:\/\/doi.org\/10.1126\/science.aao5774","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732810717.793569650","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.732810717.793544103","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.732810717.793572678","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]}}}