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The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. To avoid a global collapse in our ability to control fungal infections and to avoid critical failures in medicine and food security, we must improve our stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.<\/jats:p>","DOI":"10.1126\/science.aap7999","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T18:05:32Z","timestamp":1526580332000},"page":"739-742","source":"Crossref","is-referenced-by-count":1548,"title":["Worldwide emergence of resistance to antifungal drugs challenges human health and food security"],"prefix":"10.1126","volume":"360","author":[{"given":"Matthew C.","family":"Fisher","sequence":"first","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London W2 1PG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-0436","authenticated-orcid":true,"given":"Nichola J.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-4178","authenticated-orcid":true,"given":"Dominique","family":"Sanglard","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, University of Lausanne and University Hospital, Lausanne CH-1011, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Gurr","sequence":"additional","affiliation":[{"name":"Department of BioSciences, University of Exeter, Exeter EX4 4QD, UK."},{"name":"Department of BioSciences, Utrecht University, Paduallaan 8, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10947"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-030117-020345"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006290"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit136"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku241"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05910-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.126"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.12.021"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0309-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12433"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2014.09.001"},{"key":"e_1_3_2_16_2","first-page":"271","article-title":"Resistance to Benomyl in powdery mildew of cucurbits","volume":"53","author":"Schroeder W. 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