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Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS. Steklov\n            <jats:italic>et al.<\/jats:italic>\n            showed that mice haploinsufficient for LZTR1 recapitulated aspects of the human disease Noonan syndrome. Their biochemical studies showed that LZTR1 associated with RAS. LZTR1 appears to function as an adaptor that promotes ubiquitination of RAS, thus inhibiting its signaling functions. Bigenzahn\n            <jats:italic>et al.<\/jats:italic>\n            found LZTR1 in a screen for proteins whose absence led to resistance to the tyrosine kinase inhibitors used to treat cancers caused by the BCR-ABL oncogene product. Their biochemical studies and genetic studies in fruitflies also showed that loss of LZTR1 led to increased activity of RAS and signaling through the mitogen-activated protein kinase pathway.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6419\" page=\"1177\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aap7607\">1177<\/jats:related-article>\n            , p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6419\" page=\"1171\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aap8210\">1171<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aap8210","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:05:30Z","timestamp":1542308730000},"page":"1171-1177","source":"Crossref","is-referenced-by-count":222,"title":["LZTR1 is a regulator of RAS ubiquitination and signaling"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5214-4570","authenticated-orcid":true,"given":"Johannes W.","family":"Bigenzahn","sequence":"first","affiliation":[{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-4000","authenticated-orcid":true,"given":"Giovanna M.","family":"Collu","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. 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