{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:51:22Z","timestamp":1793267482546,"version":"4.5.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6393","funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1128928"],"award-info":[{"award-number":["OPP1128928"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["50185"],"award-info":[{"award-number":["50185"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chan Zuckerberg Biohub"},{"name":"March of Dimes Prematurity Initiative","award":["21-FY08-539"],"award-info":[{"award-number":["21-FY08-539"]}],"id":[{"id":"https:\/\/ror.org\/04bd5p711","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,6,8]]},"abstract":"<jats:title>Toward more predictable birthdays<\/jats:title>\n                  <jats:p>\n                    Low-cost methods for monitoring fetal development could improve prenatal care, especially in low-resource settings. By measuring the levels of certain placental RNA transcripts in maternal blood, Ngo\n                    <jats:italic>et al.<\/jats:italic>\n                    developed two noninvasive blood tests that provide a window into the progression of individual pregnancies. In a small proof-of-concept study, the first blood test predicted fetal age and delivery date with an accuracy comparable to that of ultrasound. The second blood test, also examined in a small pilot study, discriminated women at risk of preterm delivery from those who delivered at full term. The next step will be to assess the reliability of the tests in large, blinded clinical trials.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6393\" page=\"1133\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aar3819\">1133<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aar3819","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T15:05:41Z","timestamp":1528383941000},"page":"1133-1136","source":"Crossref","is-referenced-by-count":262,"title":["Noninvasive blood tests for fetal development predict gestational age and preterm delivery"],"prefix":"10.1126","volume":"360","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-8983","authenticated-orcid":true,"given":"Thuy T. M.","family":"Ngo","sequence":"first","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-4057","authenticated-orcid":true,"given":"Mira N.","family":"Moufarrej","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-593X","authenticated-orcid":true,"given":"Marie-Louise H.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institute, Copenhagen 2300, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-8132","authenticated-orcid":true,"given":"Joan","family":"Camunas-Soler","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-7038","authenticated-orcid":true,"given":"Wenying","family":"Pan","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-5420","authenticated-orcid":true,"given":"Norma F.","family":"Neff","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Statistics, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-6936","authenticated-orcid":true,"given":"Ronald J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-9979","authenticated-orcid":true,"given":"Katheryne","family":"Downes","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-5090","authenticated-orcid":true,"given":"Robert","family":"Tibshirani","sequence":"additional","affiliation":[{"name":"Department of Statistics, Stanford University, Stanford, CA 94305, USA."},{"name":"Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-4914","authenticated-orcid":true,"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-1271","authenticated-orcid":true,"given":"Line","family":"Skotte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institute, Copenhagen 2300, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-7206","authenticated-orcid":true,"given":"Joseph R.","family":"Biggio","sequence":"additional","affiliation":[{"name":"Center for Women\u2019s Reproductive Health, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7554-7180","authenticated-orcid":true,"given":"Michal A.","family":"Elovitz","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6785","authenticated-orcid":true,"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institute, Copenhagen 2300, Denmark."},{"name":"Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-0809","authenticated-orcid":true,"given":"Stephen R.","family":"Quake","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"291","article-title":"Paidopoi\u00efa: Metaphors for conception, abortion, and gestation in the Hippocratic Corpus","volume":"27","author":"Hanson A. E.","year":"1995","unstructured":"A. E. Hanson, Paidopoi\u00efa: Metaphors for conception, abortion, and gestation in the Hippocratic Corpus. Clio Med. 27, 291\u2013307 (1995). 7705049","journal-title":"Clio Med."},{"key":"e_1_3_2_3_2","first-page":"589","article-title":"The eight months\u2019 child and the etiquette of birth: Obsit omen!","volume":"61","author":"Hanson A. E.","year":"1987","unstructured":"A. E. Hanson, The eight months\u2019 child and the etiquette of birth: Obsit omen! Bull. Hist. Med. 61, 589\u2013602 (1987). 3322453","journal-title":"Bull. Hist. Med."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cq\/49.2.515"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000172419.37410.eb"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000458409"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.06.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127601"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.065"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007058.pub3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_3_2_12_2","unstructured":"Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes Preterm Birth: Causes Consequences and Prevention (National Academies Press 2007)."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000189091.35982.85"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1375\/twin.12.4.333"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612665"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904308"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/201628"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405528111"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-9-1281"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00087.2012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5163"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.102"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005458"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.09.007"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9847-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.059261"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160440"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2007.n.006"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.02.001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10030174.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxm030"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1515\/1544-6115.1826"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks042"},{"key":"e_1_3_2_39_2","unstructured":"M. Waskom et al. mwaskom\/seaborn: v0.8.1. Github (2017)."},{"key":"e_1_3_2_40_2","first-page":"312","article-title":"Maternal serum screening for neural tube defects and fetal chromosome abnormalities","volume":"159","author":"Rose N. C.","year":"1993","unstructured":"N. C. Rose, M. T. Mennuti, Maternal serum screening for neural tube defects and fetal chromosome abnormalities. West. J. Med. 159, 312\u2013317 (1993). 7694429","journal-title":"West. J. Med."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw797"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aar3819","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aar3819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T11:59:20Z","timestamp":1705319960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aar3819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":40,"journal-issue":{"issue":"6393","published-print":{"date-parts":[[2018,6,8]]}},"alternative-id":["10.1126\/science.aar3819"],"URL":"https:\/\/doi.org\/10.1126\/science.aar3819","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,8]]}}}