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Taking advantages of the distinctive enzymatic properties of CRISPR enzymes, Gootenberg\n et al.<\/jats:italic>\n developed an improved nucleic acid detection technology for multiplexed quantitative and highly sensitive detection, combined with lateral flow for visual readout. Myhrvold\n et al.<\/jats:italic>\n added a sample preparation protocol to create a field-deployable viral diagnostic platform for rapid detection of specific strains of pathogens in clinical samples. Cas12a (also known as Cpf1), a type V CRISPR protein, cleaves double-stranded DNA and has been adapted for genome editing. Chen\n et al.<\/jats:italic>\n discovered that Cas12a also processes single-stranded DNA threading activity. A technology platform based on this activity detected human papillomavirus in patient samples with high sensitivity.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 439<\/jats:related-article>\n , p.\n 444<\/jats:related-article>\n , p.\n 436<\/jats:related-article>\n ; see also p.\n 381<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.aas8836","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T14:05:49Z","timestamp":1524751549000},"page":"444-448","source":"Crossref","is-referenced-by-count":1411,"title":["Field-deployable viral diagnostics using CRISPR-Cas13"],"prefix":"10.1126","volume":"360","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-184X","authenticated-orcid":true,"given":"Cameron","family":"Myhrvold","sequence":"first","affiliation":[{"name":"Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA."},{"name":"Center for Systems Biology, Department of 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