{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:04:18Z","timestamp":1790125458597,"version":"4.0.1"},"reference-count":0,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6373","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,1,19]]},"abstract":"<jats:p>\n            Combating a disease of unknown cause is a daunting task. One hundred years ago, a pandemic of poorly understood etiology and transmissibility spread worldwide, causing an estimated 50 million deaths. Initially attributed to\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            , it was not until the 1930s that an H1 subtype was identified as the causative strain. Subsequent influenza pandemics in 1957, 1968, and 2009 did not approach levels of morbidity and mortality comparable to those of the 1918 \u201cSpanish flu,\u201d leaving unanswered for almost a century questions regarding the extraordinary virulence and transmissibility of this unique strain. Technological advances made reconstruction of the 1918 virus possible; now, continued research, vaccine development, and preparedness are essential to ensure that such a devastating public health event is not repeated.\n          <\/jats:p>","DOI":"10.1126\/science.aas9565","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T18:45:39Z","timestamp":1516301139000},"page":"255-255","source":"Crossref","is-referenced-by-count":24,"title":["The 1918 flu, 100 years later"],"prefix":"10.1126","volume":"359","author":[{"given":"Jessica A.","family":"Belser","sequence":"first","affiliation":[{"name":"Jessica A. Belser is a microbiologist in the Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence M.","family":"Tumpey","sequence":"additional","affiliation":[{"name":"Terrence M. Tumpey is chief of the Immunology and Pathogenesis Branch in the Influenza Division of the CDC, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aas9565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T17:11:22Z","timestamp":1705338682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aas9565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":0,"journal-issue":{"issue":"6373","published-print":{"date-parts":[[2018,1,19]]}},"alternative-id":["10.1126\/science.aas9565"],"URL":"https:\/\/doi.org\/10.1126\/science.aas9565","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]}}}