{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:35:32Z","timestamp":1792452932785,"version":"4.5.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6424","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,1,18]]},"abstract":"<jats:title>Serotherapy treats a transplant hurdle<\/jats:title>\n          <jats:p>\n            Cytomegalovirus (CMV) infection and reactivation are common and potentially fatal complications after bone marrow or hematopoietic stem cell transplantation (BMT). Martins\n            <jats:italic>et al.<\/jats:italic>\n            developed faithful preclinical murine models of CMV reactivation following BMT and found that humoral immunity can prevent this process (see the Perspective by Alegre). After BMT, antiviral antibodies that would have kept CMV at bay dwindle because host plasma cells are ablated and the donor B cell pool reconstitutes poorly. CMV reactivation was prevented by transferring antibody-containing immune serum. Such a therapeutic strategy would avoid some limitations of cellular therapies for BMT patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6424\" page=\"288\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aat0066\">288<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6424\" page=\"232\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aav9867\">232<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aat0066","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:16:30Z","timestamp":1547770590000},"page":"288-293","source":"Crossref","is-referenced-by-count":64,"title":["Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation"],"prefix":"10.1126","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-403X","authenticated-orcid":true,"given":"Jose Paulo","family":"Martins","sequence":"first","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia."},{"name":"School of Medicine, University of Queensland, Brisbane, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-3180","authenticated-orcid":true,"given":"Christopher E.","family":"Andoniou","sequence":"additional","affiliation":[{"name":"Immunology and Virology Program, Centre for Ophthalmology and 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