{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:56:09Z","timestamp":1790783769236,"version":"4.1.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6394","funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR13W1"],"award-info":[{"award-number":["JPMJCR13W1"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004398","name":"Mitsubishi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004398","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["JP23220009"],"award-info":[{"award-number":["JP23220009"]}]},{"name":"JSPS KAKENHI","award":["JP 25830007"],"award-info":[{"award-number":["JP 25830007"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology, Japan","doi-asserted-by":"crossref","award":["JP25115002"],"award-info":[{"award-number":["JP25115002"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>Disentangling specific memories<\/jats:title>\n          <jats:p>\n            Each memory is stored in a distinct memory trace in the brain, in a specific population of neurons called engram cells. How does the brain store and define the identity of a specific memory when two memories interact and are encoded in a shared engram? Abdou\n            <jats:italic>et al.<\/jats:italic>\n            used optogenetic reactivation coupled with manipulations of long-term potentiation to analyze engrams that share neurons in the lateral amygdala (see the Perspective by Ramirez). Synapse-specific plasticity guaranteed the storage and the identity of individual memories in a shared engram. Moreover, synaptic plasticity between specific engram assemblies was necessary and sufficient for memory engram formation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6394\" page=\"1227\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aat3810\">1227<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6394\" page=\"1182\" related-article-type=\"in-this-issue\" vol=\"360\" xlink:href=\"10.1126\/science.aau0043\">1182<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aat3810","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T18:10:41Z","timestamp":1528999841000},"page":"1227-1231","source":"Crossref","is-referenced-by-count":204,"title":["Synapse-specific representation of the identity of overlapping memory engrams"],"prefix":"10.1126","volume":"360","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-1650","authenticated-orcid":true,"given":"Kareem","family":"Abdou","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan."},{"name":"Japan Science and Technology Agency, CREST, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-3009","authenticated-orcid":true,"given":"Mohammad","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan."},{"name":"Japan Science and Technology Agency, CREST, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriko","family":"Choko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan."},{"name":"Japan Science and Technology Agency, CREST, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nishizono","sequence":"additional","affiliation":[{"name":"Japan Science and Technology Agency, CREST, University of Toyama, Toyama 930-0194, Japan."},{"name":"Division of Animal Experimental Laboratory, Life Science Research Center, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Animal Experimental Laboratory, Life Science Research Center, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-7790","authenticated-orcid":true,"given":"Shin-ichi","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi 3290498, Japan."},{"name":"Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-3133","authenticated-orcid":true,"given":"Kaoru","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan."},{"name":"Japan Science and Technology Agency, CREST, University of Toyama, Toyama 930-0194, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010273"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13294"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2303"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.07.009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164139"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4000"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11028"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1143839"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174519"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17955"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12319"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.017"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf0594"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal2690"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3667"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.08.004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5542"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3945"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2014-0002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4533-11.2012"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3505-17.2018"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000133"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31069"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00645-1"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20753"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/974819"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.08.009"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aat3810","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aat3810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T22:42:04Z","timestamp":1705358524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aat3810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":31,"journal-issue":{"issue":"6394","published-print":{"date-parts":[[2018,6,15]]}},"alternative-id":["10.1126\/science.aat3810"],"URL":"https:\/\/doi.org\/10.1126\/science.aat3810","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,15]]}}}