{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:17:41Z","timestamp":1790626661418,"version":"4.1.0"},"reference-count":75,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6412","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT098051"],"award-info":[{"award-number":["WT098051"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/K018809\/1"],"award-info":[{"award-number":["BB\/K018809\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31671372, 31701739, 61702406"],"award-info":[{"award-number":["31671372, 31701739, 61702406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National key R and D program of China","award":["2017YFC0907500"],"award-info":[{"award-number":["2017YFC0907500"]}]},{"name":"Thousand Talents Plan\u201d and by Key Construction Program of the National \u201c985\u201d Project"},{"DOI":"10.13039\/100013999","name":"The Garfield Weston Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013999","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,10,19]]},"abstract":"<jats:title>Poppy genome reveals evolution of opiates<\/jats:title>\n          <jats:p>\n            The opium poppy has been a source of painkillers since Neolithic times. Attendant risks of addiction threaten many today. Guo\n            <jats:italic>et al.<\/jats:italic>\n            now deliver a draft of the opium poppy genome, which encompasses 2.72 gigabases assembled into 11 chromosomes and predicts more than 50,000 protein-coding genes. A particularly complex gene cluster contains many critical enzymes in the metabolic pathway that generates the alkaloid drugs noscapine and morphinan.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6412\" page=\"343\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aat4096\">343<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aat4096","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T18:05:16Z","timestamp":1535652316000},"page":"343-347","source":"Crossref","is-referenced-by-count":333,"title":["The opium poppy genome and morphinan production"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-3481","authenticated-orcid":true,"given":"Li","family":"Guo","sequence":"first","affiliation":[{"name":"MOE Key Lab for Intelligent Networks and Networks Security, School of Electronics and Information Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."},{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710061 China."},{"name":"The School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Winzer","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-7755","authenticated-orcid":true,"given":"Xiaofei","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Lab for Intelligent Networks and Networks Security, School of Electronics and Information Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."},{"name":"Computer Science Department, School of Electronics and Information Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-7185","authenticated-orcid":true,"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Ning","sequence":"additional","affiliation":[{"name":"The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-9876","authenticated-orcid":true,"given":"Zhesi","family":"He","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-1894","authenticated-orcid":true,"given":"Roxana","family":"Teodor","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-9209","authenticated-orcid":true,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Ocean University, Shanghai, 201306 China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Bowser","sequence":"additional","affiliation":[{"name":"Sun Pharmaceutical Industries Australia, Princes Highway, Port Fairy, VIC 3284, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-1770","authenticated-orcid":true,"given":"Ian A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-6741","authenticated-orcid":true,"given":"Kai","family":"Ye","sequence":"additional","affiliation":[{"name":"MOE Key Lab for Intelligent Networks and Networks Security, School of Electronics and Information Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."},{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710061 China."},{"name":"The School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an, 710049 China."},{"name":"Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00334-007-0138-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32513-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01588a033"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9373"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10390"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220757"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1852"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1879"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0411s48"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv351"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06148"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3813"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0721-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss075"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-1-r3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx305"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.129"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0059-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1293"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.161315"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"R. Magnavaca C. O. Gardner R. B. Clark \u201cEvaluation of inbred maize lines for aluminum tolerance in nutrient solution\u201d in Genetic Aspects of Plant Mineral Nutrition. Developments in Plant and Soil Sciences W. H. Gabelman B. C. Loughman Eds. (Springer 1987) vol. 27 pp. 255\u2013265.","DOI":"10.1007\/978-94-009-3581-5_23"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"A. C. Frazee et al . Flexible analysis of transcriptome assemblies with Ballgown. bioRxiv 003665 [Preprint]. 5 September 2014. .10.1101\/003665","DOI":"10.1101\/003665"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1883"},{"key":"e_1_3_2_28_2","unstructured":"M. J. Raymond \u201cIsolation and characterization of latex-specific promoters from Papaver somniferum \u201d thesis Virginia Polytechnic Institute and State University (2004)."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.215087.116"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.065"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.214874.116"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20098"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41438-017-0011-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3865"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan0032"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24486"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-017-0067-8"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00353"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7914"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0573-1"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4035"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-090414-014900"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4432"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq268"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-015-0041-9"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-31"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr010"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-5-59"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki937"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1090"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12817"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu031"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/619832"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.5.0955"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn766"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030056"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2238404"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06967"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-0229(10)60008-3"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh340"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl446"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2016-021"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-5-r41"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.127597"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.26"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22380"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11119"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1224503"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp348"},{"key":"e_1_3_2_74_2","first-page":"Unit 2.3","article-title":"Multiple sequence alignment using ClustalW and ClustalX","volume":"2","author":"Thompson J. D.","year":"2002","unstructured":"J. D. Thompson, T. Gibson, D. G. Higgins, Multiple sequence alignment using ClustalW and ClustalX. Curr. Protoc. Bioinformatics Chapter 2, Unit 2.3 (2002). 18792934","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026334"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_2_77_2","doi-asserted-by":"crossref","unstructured":"M. Bastian S. Heymann M. Jacomy Gephi: an open source software for exploring and manipulating networks International AAAI Conference on Weblogs and Social Media (2009); http:\/\/gephi.org.","DOI":"10.1609\/icwsm.v3i1.13937"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aat4096","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aat4096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:44:35Z","timestamp":1705365875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aat4096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":75,"journal-issue":{"issue":"6412","published-print":{"date-parts":[[2018,10,19]]}},"alternative-id":["10.1126\/science.aat4096"],"URL":"https:\/\/doi.org\/10.1126\/science.aat4096","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]}}}