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Pons-Salort and Grassly used Japanese surveillance data to model the interplay between the ratio of susceptible and immune individuals, accounting for declining birth and death rates, incomplete surveillance, and seasonality of infection (see the Perspective by Nikolay and Cauchemez). Enteroviruses have highly predictable yet highly nonlinear dynamics. The model also reveals signatures of increased pathogenicity and of antigenic change and transmissibility.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6404\" page=\"800\" related-article-type=\"in-this-issue\" vol=\"361\" xlink:href=\"10.1126\/science.aat6777\">800<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6404\" page=\"755\" related-article-type=\"in-this-issue\" vol=\"361\" xlink:href=\"10.1126\/science.aau6932\">755<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aat6777","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:54:36Z","timestamp":1535032476000},"page":"800-803","source":"Crossref","is-referenced-by-count":121,"title":["Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses"],"prefix":"10.1126","volume":"361","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-9285","authenticated-orcid":true,"given":"Margarita","family":"Pons-Salort","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, London W2 1PG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-4507","authenticated-orcid":true,"given":"Nicholas C.","family":"Grassly","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, London W2 1PG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"M. 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