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Such an anticancer strategy could be based on the ErbB family of receptors that is activated in many cancers. Chung\n            <jats:italic>et al.<\/jats:italic>\n            developed a cell-killing circuit that is activated by excessive ErbB signaling and used a viral delivery system to add it to cells. The ErbB receptor proteins are tyrosine kinases that autophosphorylate. The authors designed a protease that would be recruited to such over-phosphorylated receptors. Once in place, the protease cleaves a protein anchored to the cell membrane, releasing it into the cytoplasm where it causes death of the transformed cells.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aat6982\">eaat6982<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aat6982","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T23:09:11Z","timestamp":1556838551000},"source":"Crossref","is-referenced-by-count":76,"title":["A compact synthetic pathway rewires cancer signaling to therapeutic effector release"],"prefix":"10.1126","volume":"364","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-2432","authenticated-orcid":true,"given":"Hokyung 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