{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:38:19Z","timestamp":1792798699238,"version":"4.5.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6419","funder":[{"DOI":"10.13039\/501100001255","name":"Lister Institute of Preventive Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001255","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["ALTF 441-2015"],"award-info":[{"award-number":["ALTF 441-2015"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Council","award":["MR\/M009629\/1"],"award-info":[{"award-number":["MR\/M009629\/1"]}]},{"name":"Universit\u00e4t Bayern e.V.","award":["Elite Advancement Ph.D. stipend"],"award-info":[{"award-number":["Elite Advancement Ph.D. stipend"]}],"id":[{"id":"https:\/\/ror.org\/01k8fm112","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,12,7]]},"abstract":"<jats:title>\n                    Actively persistent\n                    <jats:italic>Salmonella<\/jats:italic>\n                  <\/jats:title>\n                  <jats:p>\n                    A proportion of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    cells can enter a reversible state of growth arrest, which allows them to tolerate environmental stress such as antibiotics. Stapels\n                    <jats:italic>et al.<\/jats:italic>\n                    found that these cells are not dormant but are actively modulating their environment.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    within their host macrophage niche deployed a specialized type 3 secretory system called SPI-2 to deliver virulence factors, including SteE, into host cells. SteE changed the cytokine profile of the infected macrophages to reprogram them into a noninflammatory and infection-permissive state. Thus, when antibiotics were removed, the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    could reemerge and cause disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6419\" page=\"1156\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aat7148\">1156<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aat7148","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T19:05:32Z","timestamp":1544123132000},"page":"1156-1160","source":"Crossref","is-referenced-by-count":380,"title":["<i>Salmonella<\/i>\n                    persisters undermine host immune defenses during antibiotic treatment"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-541X","authenticated-orcid":true,"given":"Daphne A. 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