{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:03:57Z","timestamp":1790053437818,"version":"4.0.1"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6430","funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DK044319, DK051362, DK053056, DK088199"],"award-info":[{"award-number":["DK044319, DK051362, DK053056, DK088199"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106260\/Z\/14\/Z"],"award-info":[{"award-number":["106260\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","award":["2689323 and 16K19162"],"award-info":[{"award-number":["2689323 and 16K19162"]}],"id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["648889"],"award-info":[{"award-number":["648889"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 4749\/1-1"],"award-info":[{"award-number":["KR 4749\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ExC306"],"award-info":[{"award-number":["ExC306"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020141","name":"Harvard Digestive Diseases Center","doi-asserted-by":"crossref","award":["DK034854"],"award-info":[{"award-number":["DK034854"]}],"id":[{"id":"10.13039\/100020141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NWO","award":["825.13.012"],"award-info":[{"award-number":["825.13.012"]}]},{"DOI":"10.13039\/100024043","name":"Pediatric Scientist Development Program","doi-asserted-by":"crossref","award":["K12-HD000850"],"award-info":[{"award-number":["K12-HD000850"]}],"id":[{"id":"10.13039\/100024043","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Stressed gut epithelium gets some relief<\/jats:title>\n                  <jats:p>\n                    Immunoglobulin A (IgA) is the most abundantly expressed antibody isotype and can be found at various mucosal surfaces in the body, including the gastrointestinal (GI) tract. IgA is polyreactive and can coat and restrain both commensal bacteria and enteric pathogens. Grootjans\n                    <jats:italic>et al.<\/jats:italic>\n                    found that endoplasmic reticulum (ER) stress in the intestinal epithelial cells of mice induced the T cell\u2013 and microbiota-independent expansion of peritoneal B1b cells, which secrete IgA. Similarly, human subjects homozygous for a variant of an autophagy gene (\n                    <jats:italic>ATG16L1<\/jats:italic>\n                    ) known to cause ER stress showed increased numbers of GI IgA\n                    <jats:sup>+<\/jats:sup>\n                    cells compared with controls. Thus, epithelial ER stress serves as an advantageous \u201ceustress\u201d response that can functionally antagonize its well-characterized role in promoting inflammation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6430\" page=\"993\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aat7186\">993<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aat7186","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T19:09:12Z","timestamp":1551380952000},"page":"993-998","source":"Crossref","is-referenced-by-count":66,"title":["Epithelial endoplasmic reticulum stress orchestrates a protective IgA response"],"prefix":"10.1126","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-4831","authenticated-orcid":true,"given":"Joep","family":"Grootjans","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."},{"name":"Amsterdam University Medical Center, University of Amsterdam, Department of Gastroenterology and Hepatology and Tygat Institute for Liver and Intestinal Research, Meibergdreef 9, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-7536","authenticated-orcid":true,"given":"Niklas","family":"Krupka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."},{"name":"Maurice M\u00fcller Laboratories (DBMR), Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-5672","authenticated-orcid":true,"given":"Shuhei","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."},{"name":"Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Matute","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."},{"name":"Division of Neonatology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-8299","authenticated-orcid":true,"given":"Thomas","family":"Hanley","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-9752","authenticated-orcid":true,"given":"Svetlana","family":"Saveljeva","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-5490","authenticated-orcid":true,"given":"Thomas","family":"Gensollen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9615-7851","authenticated-orcid":true,"given":"Jarom","family":"Heijmans","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Center, University of Amsterdam, Department of Internal Medicine, Tygat Institute for Liver and Intestinal Research, Meibergdreef 9, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories (DBMR), Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-3492","authenticated-orcid":true,"given":"Julien P.","family":"Limenitakis","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories (DBMR), Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-7754","authenticated-orcid":true,"given":"Stephanie C.","family":"Ganal-Vonarburg","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories (DBMR), Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbao","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne M.","family":"Luoma","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-9196","authenticated-orcid":true,"given":"Yosuke","family":"Shimodaira","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-4956","authenticated-orcid":true,"given":"Jinzhi","family":"Duan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-7044","authenticated-orcid":true,"given":"David Q.","family":"Shih","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-8159","authenticated-orcid":true,"given":"Margaret E.","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-2655","authenticated-orcid":true,"given":"Jonathan N.","family":"Glickman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenny M.","family":"Fuhler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-9455","authenticated-orcid":true,"given":"Noah W.","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel R.","family":"de Zoete","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-6957","authenticated-orcid":true,"given":"C. Janneke","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Cheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-302X","authenticated-orcid":true,"given":"Kai W.","family":"Wucherpfennig","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan R.","family":"Targan","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenstiel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin-Str. 12, 24105 Kiel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-0778","authenticated-orcid":true,"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-9227","authenticated-orcid":true,"given":"Kathy D.","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-0184","authenticated-orcid":true,"given":"Andrew J.","family":"Macpherson","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories (DBMR), Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-3344","authenticated-orcid":true,"given":"Arthur","family":"Kaser","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-248X","authenticated-orcid":true,"given":"Richard S.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.62"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025589"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.033"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12599"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3322"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12189"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.312"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20912"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160791"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00779-06"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.023"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917328"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan1217"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85113"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.915"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5474.2222"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2007.6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.5.643"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2901"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.007"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2322"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6619"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00088-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303527"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.4049\/jimmunol.162.5.2521","article-title":"Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes","volume":"162","author":"Harriman G. R.","year":"1999","unstructured":"G. R. Harriman, M. Bogue, P. Rogers, M. Finegold, S. Pacheco, A. Bradley, Y. Zhang, I. N. Mbawuike, Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J. Immunol. 162, 2521\u20132529 (1999). 10072491","journal-title":"J. Immunol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315792111"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20042"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3791\/1488"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.055"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.091"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3791\/50556"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3364"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-014-0040-5"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.1.209"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004503"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.22"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aat7186","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aat7186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T19:47:44Z","timestamp":1705348064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aat7186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":47,"journal-issue":{"issue":"6430","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1126\/science.aat7186"],"URL":"https:\/\/doi.org\/10.1126\/science.aat7186","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}