{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:24:15Z","timestamp":1791246255178,"version":"4.1.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6419","funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1086217"],"award-info":[{"award-number":["OPP1086217"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1141300"],"award-info":[{"award-number":["OPP1141300"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1023601"],"award-info":[{"award-number":["OPP1023601"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1023601"],"award-info":[{"award-number":["OPP1023601"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,12,7]]},"abstract":"<jats:title>A path to tackle liver-stage parasites<\/jats:title>\n                  <jats:p>\n                    Malaria parasites are evolutionarily prepared to resist drug attack. Resistance is emerging to even the latest frontline combination therapies, which target the blood stages of the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasite. As an alternative strategy, Antonova-Koch\n                    <jats:italic>et al.<\/jats:italic>\n                    investigated the possibilities of drugs against liver-stage parasites (see the Perspective by Phillips and Goldberg). To do so, they devised a luciferase-reporter drug screen for the rodent parasite\n                    <jats:italic>Plasmodium berghei.<\/jats:italic>\n                    Three rounds of increasingly stringent screening were used. From this regime, several chemotypes that inhibit\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    mitochondrial electron transport were identified. Excitingly, several new scaffolds, with as-yet-unknown modes of action but solely targeting the parasites' liver stages, emerged as promising drug leads for further development.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aat9446\">eaat9446<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6419\" page=\"1112\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aav7479\">1112<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aat9446","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T19:05:32Z","timestamp":1544123132000},"source":"Crossref","is-referenced-by-count":143,"title":["Open-source discovery of chemical leads for next-generation chemoprotective antimalarials"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-0407","authenticated-orcid":true,"given":"Yevgeniya","family":"Antonova-Koch","sequence":"first","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-7037","authenticated-orcid":true,"given":"Stephan","family":"Meister","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-4443","authenticated-orcid":true,"given":"Matthew","family":"Abraham","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-1200","authenticated-orcid":true,"given":"Madeline R.","family":"Luth","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Ottilie","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-7643","authenticated-orcid":true,"given":"Amanda K.","family":"Lukens","sequence":"additional","affiliation":[{"name":"Harvard T. 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Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA."},{"name":"The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-5101","authenticated-orcid":true,"given":"Tomoyo","family":"Sakata-Kato","sequence":"additional","affiliation":[{"name":"The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-2347","authenticated-orcid":true,"given":"Manu","family":"Vanaerschot","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-4658","authenticated-orcid":true,"given":"Edward","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Jado","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-5656","authenticated-orcid":true,"given":"Steven P.","family":"Maher","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D. 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