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Chui\n                    <jats:italic>et al.<\/jats:italic>\n                    used genome-wide knockout screens to show that proteolysis of NLRP1B by lethal factor induces proteasomal degradation of the amino-terminal domains of NLRP1B and eventual cell death. Sandstrom\n                    <jats:italic>et al.<\/jats:italic>\n                    found that degradation of the amino-terminal domains of NLRP1B resulted in the release of a carboxyl-terminal fragment that activates caspase-1. This process, called \u201cfunctional degradation,\u201d allows the immune system to detect pathogen-associated activities, much as it recognizes pathogen-associated antigens.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6435\" page=\"82\" related-article-type=\"in-this-issue\" vol=\"364\" xlink:href=\"10.1126\/science.aau1208\">82<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau1330\">eaau1330<\/jats:related-article>\n                  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