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Alam\n            <jats:italic>et al.<\/jats:italic>\n            have taken established drug targets\u2014CLK protein kinases involved in regulation of RNA splicing\u2014and investigated how inhibition of the parasite's enzymes blocks completion of its complex life cycle. They identified an inhibitor of the parasite's CLK protein kinase that was 100-fold less active against the most closely related human protein kinase and effective at clearing rodent malaria parasites. Not only does this compound halt the development of sexual stages but it also limits transmission to the mosquito vector of the parasite, a key requirement for malaria drugs.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau1682\">eaau1682<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aau1682","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T23:04:12Z","timestamp":1567119852000},"source":"Crossref","is-referenced-by-count":66,"title":["Validation of the protein kinase\n            <i>Pf<\/i>\n            CLK3 as a multistage cross-species malarial drug target"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2148-4887","authenticated-orcid":true,"given":"Mahmood M.","family":"Alam","sequence":"first","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-3251","authenticated-orcid":true,"given":"Ana","family":"Sanchez-Azqueta","sequence":"additional","affiliation":[{"name":"Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-2396","authenticated-orcid":true,"given":"Omar","family":"Janha","sequence":"additional","affiliation":[{"name":"Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-7954","authenticated-orcid":true,"given":"Erika L.","family":"Flannery","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research, Emeryville, CA 94608, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-2466","authenticated-orcid":true,"given":"Amit","family":"Mahindra","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kopano","family":"Mapesa","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-1244","authenticated-orcid":true,"given":"Aditya B.","family":"Char","sequence":"additional","affiliation":[{"name":"Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow G12 8QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-1420","authenticated-orcid":true,"given":"Dev","family":"Sriranganadane","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-886, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-3266","authenticated-orcid":true,"given":"Nicolas M. 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