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This difference is regulated by opening or closing ion channels in the cell membrane. For example, mutations in human voltage-gated sodium (Na\n                    <jats:sub>v<\/jats:sub>\n                    ) channels are associated with disorders such as chronic pain, epilepsy, and cardiac arrhythmia. Pan\n                    <jats:italic>et al.<\/jats:italic>\n                    report the high-resolution structure of a human Na\n                    <jats:sub>v<\/jats:sub>\n                    channel, and Shen\n                    <jats:italic>et al.<\/jats:italic>\n                    report the structures of an insect Na\n                    <jats:sub>v<\/jats:sub>\n                    channel bound to the toxins that cause pufferfish and shellfish poisoning in humans. Together, the structures give insight into the molecular basis of sodium ion permeation and provide a path toward structure-based drug discovery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau2486\">eaau2486<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau2596\">eaau2596<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau2596","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T14:06:54Z","timestamp":1532614014000},"source":"Crossref","is-referenced-by-count":264,"title":["Structural basis for the modulation of voltage-gated sodium channels by animal toxins"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-5393","authenticated-orcid":true,"given":"Huaizong","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Membrane Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-2293","authenticated-orcid":true,"given":"Zhangqiang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-804X","authenticated-orcid":true,"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-5361","authenticated-orcid":true,"given":"Xiaojing","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-7691","authenticated-orcid":true,"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."},{"name":"Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-2029","authenticated-orcid":true,"given":"Ben","family":"Cristofori-Armstrong","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-6897","authenticated-orcid":true,"given":"Yanni K. 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