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Inflammasome complexes can initiate both the maturation of inflammatory cytokines and pyroptotic cell death via the caspase-mediated cleavage of gasdermin D (GSDMD). As of now, the only known regulators of GSDMD in macrophages are caspase-1 and caspase-11. Orning\n                    <jats:italic>et al.<\/jats:italic>\n                    report an additional pathway controlling GSDMD processing. YopJ, an effector molecule produced by\n                    <jats:italic>Yersinia<\/jats:italic>\n                    (the causative agent of plague), inhibits TAK1\u2013I\u03baB kinase signaling. This, in turn, results in caspase-8\u2013directed cleavage of GSDMD, pyroptosis, and the release of interleukin 1\u03b2 (IL-1\u03b2) and IL-18. Thus, in the arms race between host and pathogen, the host recognizes signaling disturbances as pathogenic and counters with inflammation and cell death.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6418\" page=\"1064\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aau2818\">1064<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau2818","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T14:15:53Z","timestamp":1540476953000},"page":"1064-1069","source":"Crossref","is-referenced-by-count":978,"title":["Pathogen blockade of TAK1 triggers caspase-8\u2013dependent cleavage of gasdermin D and cell 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