{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:03:39Z","timestamp":1792803819355,"version":"4.5.0"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6441","funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 1095-2015"],"award-info":[{"award-number":["ALTF 1095-2015"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["FRA 1184902 HFST-P"],"award-info":[{"award-number":["FRA 1184902 HFST-P"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["743216"],"award-info":[{"award-number":["743216"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-43 BRAIN Dolipran"],"award-info":[{"award-number":["ANR-10-LABX-43 BRAIN Dolipran"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ING20150532192"],"award-info":[{"award-number":["ING20150532192"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"France-BioImaging","award":["Access-1576"],"award-info":[{"award-number":["Access-1576"]}],"id":[{"id":"https:\/\/ror.org\/01y7vt929","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,5,17]]},"abstract":"<jats:title>Local translation in presynaptic terminals<\/jats:title>\n                  <jats:p>\n                    Proteins carry out most of the functions in cells, including neurons, which are one of the most morphologically complex cell types in the body. This poses challenges for how proteins can be supplied to remote regions where connections (synapses) are made with other neurons. One solution to the neuron protein-supply problem involves the local synthesis of proteins from messenger RNA (mRNA) molecules located at or near synapses. Hafner\n                    <jats:italic>et al.<\/jats:italic>\n                    used RNA sequencing methods and superresolution microscopy to show that axon terminals contain hundreds of mRNA molecules as well as the machinery needed for protein synthesis. Furthermore, the axon terminals were able to use these components to make proteins that participate in synaptic transmission.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau3644\">eaau3644<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau3644","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T19:05:16Z","timestamp":1558033516000},"source":"Crossref","is-referenced-by-count":462,"title":["Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments"],"prefix":"10.1126","volume":"364","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-7307","authenticated-orcid":true,"given":"Anne-Sophie","family":"Hafner","sequence":"first","affiliation":[{"name":"Max Planck Institute for Brain Research, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6309-6535","authenticated-orcid":true,"given":"Paul G.","family":"Donlin-Asp","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Brain Research, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-3134","authenticated-orcid":true,"given":"Beulah","family":"Leitch","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-6959","authenticated-orcid":true,"given":"Etienne","family":"Herzog","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F-33000, Bordeaux, France."},{"name":"Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, F-33000, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-1005","authenticated-orcid":true,"given":"Erin M.","family":"Schuman","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Brain Research, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903600112"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34202"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.058"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3546"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.044"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22574"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.05.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22109"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.036"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00551-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2010.01118.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1775"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200703209"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0847-y"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.029"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.040"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36697"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.4.1284"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio244162a0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.04.017.2009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80099-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3625"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-22-j0001.2001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00344-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/39908"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01279-9"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6688-2_10"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201386120"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0900293"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2073-11.2011"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.004"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.013"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1314"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08300.1998"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3319"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5280.1402"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.321"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-17"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3432-06.2006"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.036"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2386111"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1800-10.2010"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00847a025"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1968.tb06172.x"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.019"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012605299"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.040"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4001"},{"key":"e_1_3_3_51_2","first-page":"192","article-title":"Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains","volume":"26","author":"Akins M. R.","year":"2017","unstructured":"M. R. Akins, H. E. Berk-Rauch, K. Y. Kwan, M. E. Mitchell, K. A. Shepard, L. I. Korsak, E. E. Stackpole, J. L. Warner-Schmidt, N. Sestan, H. A. Cameron, J. R. Fallon, Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains. Hum. Mol. Genet. 26, 192\u2013209 (2017). 28082376","journal-title":"Hum. Mol. Genet."},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5469.1254"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.015"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.030"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00295-1"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.013"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2396-15.2016"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0047-3"},{"key":"e_1_3_3_59_2","unstructured":"Genome Reference Consortium Mouse Build 38 mm10 (2011); http:\/\/hgdownload.soe.ucsc.edu\/goldenPath\/mm10\/bigZips\/."},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_3_61_2","unstructured":"Genomics Institute UCSC Table Browser; http:\/\/genome.ucsc.edu\/cgi-bin\/hgTables?hgsid=706713641_R7J6gGZbwmO18wecxAAiXglgAlzN&clade=mammal&org=Mouse&db=mm10&hgta_group=genes&hgta_track=refSeqComposite&hgta_table=0&hgta_regionType=genome&position=chr12%3A56694976-56714605&hgta_outputType=primaryTable&hgta_outFileName=."},{"key":"e_1_3_3_62_2","unstructured":"Walter and Eliza Hall Institute featureCounts: a ultrafast and accurate read summarization program; http:\/\/bioinf.wehi.edu.au\/featureCounts\/."},{"key":"e_1_3_3_63_2","unstructured":"Bioconductor DESeq2; https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/DESeq2.html."},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks042"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.229202"},{"key":"e_1_3_3_67_2","unstructured":"J. C. Oliveros (2015). Venny. An interactive tool for comparing lists with Venn\u2019s diagrams; http:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aau3644","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aau3644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:54:43Z","timestamp":1705344883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aau3644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,17]]},"references-count":66,"journal-issue":{"issue":"6441","published-print":{"date-parts":[[2019,5,17]]}},"alternative-id":["10.1126\/science.aau3644"],"URL":"https:\/\/doi.org\/10.1126\/science.aau3644","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735775241.793560423","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735775241.793563562","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735775241.793562646","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735775241.793561025","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/363184","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,17]]},"article-number":"eaau3644"}}