{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:02:09Z","timestamp":1790949729733,"version":"4.1.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6449","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK030292"],"award-info":[{"award-number":["DK030292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI043596"],"award-info":[{"award-number":["AI043596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1134649"],"award-info":[{"award-number":["OPP1134649"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,7,12]]},"abstract":"<jats:title>Malnutrition and dietary repair<\/jats:title>\n                  <jats:p>\n                    Childhood malnutrition is accompanied by growth stunting and immaturity of the gut microbiota. Even after therapeutic intervention with standard commercial complementary foods, children may fail to thrive. Gehrig\n                    <jats:italic>et al.<\/jats:italic>\n                    and Raman\n                    <jats:italic>et al.<\/jats:italic>\n                    monitored metabolic parameters in healthy Bangladeshi children and those recovering from severe acute malnutrition. The authors investigated the interactions between therapeutic diet, microbiota development, and growth recovery. Diets were then designed using pig and mouse models to nudge the microbiota into a mature post-weaning state that might be expected to support the growth of a child. These were first tested in mice inoculated with age-characteristic gut microbiota. The designed diets entrained maturation of the children's microbiota and put their metabolic and growth profiles on a healthier trajectory.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau4732\">eaau4732<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau4735\">eaau4735<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau4735","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T12:46:55Z","timestamp":1565354815000},"source":"Crossref","is-referenced-by-count":214,"title":["A sparse covarying unit that describes healthy and impaired human gut microbiota development"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-7272","authenticated-orcid":true,"given":"Arjun S.","family":"Raman","sequence":"first","affiliation":[{"name":"Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-8897","authenticated-orcid":true,"given":"Jeanette 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Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-677X","authenticated-orcid":true,"given":"Matthew C.","family":"Hibberd","sequence":"additional","affiliation":[{"name":"Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Center for Gut 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Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia."},{"name":"Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-9824","authenticated-orcid":true,"given":"Andrei L.","family":"Osterman","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeeda","family":"Huq","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Mostafa","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease 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