{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:37:34Z","timestamp":1792798654034,"version":"4.5.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6413","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE022358, R35 NS105067"],"award-info":[{"award-number":["R01 DE022358, R35 NS105067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 AT009497, OT2 OD023848"],"award-info":[{"award-number":["DP1 AT009497, OT2 OD023848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL14388"],"award-info":[{"award-number":["P01 HL14388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL14388"],"award-info":[{"award-number":["P01 HL14388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"George Hewitt Foundation for Medical Research","id":[{"id":"https:\/\/ror.org\/05npsb488","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2018,10,26]]},"abstract":"<jats:title>Heart rate and blood pressure control<\/jats:title>\n                  <jats:p>\n                    PIEZO1 and PIEZO2 are two mechanically activated ion channels that are highly expressed in lungs, bladder, and skin. Zeng\n                    <jats:italic>et al.<\/jats:italic>\n                    found that both ion channels are expressed in sensory neurons of a ganglion complex that contribute to the baroreflex, a homeostatic mechanism that helps to keep blood pressure stable (see the Perspective by Ehmke). Conditional double knockout of PIEZO1 and PIEZO2 in these neurons abolished the baroreflex and disrupted blood pressure regulation and heart rates in mice. These changes were very similar to those seen in patients with baroreflex failure. In mice, selective activation of PIEZO2-expressing ganglion neurons triggered immediate increases in heart rate and blood pressure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6413\" page=\"464\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aau6324\">464<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6413\" page=\"398\" related-article-type=\"in-this-issue\" vol=\"362\" xlink:href=\"10.1126\/science.aav3495\">398<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau6324","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T17:53:00Z","timestamp":1541181180000},"page":"464-467","source":"Crossref","is-referenced-by-count":501,"title":["PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex"],"prefix":"10.1126","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-032X","authenticated-orcid":true,"given":"Wei-Zheng","family":"Zeng","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-7941","authenticated-orcid":true,"given":"Kara L.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-2935","authenticated-orcid":true,"given":"Soohong","family":"Min","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Daou","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-931X","authenticated-orcid":true,"given":"Mark W.","family":"Chapleau","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine and Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Veterans Affairs Medical Center, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-9148","authenticated-orcid":true,"given":"Francois M.","family":"Abboud","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine and Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Liberles","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-7034","authenticated-orcid":true,"given":"Ardem","family":"Patapoutian","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00008-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1976.56.1.100"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3450"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80661-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602812"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02704-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02703-w"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.92"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87343"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.072"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20793"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4162"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13980"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.20.4065"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311113292003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000160355.93303.72"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017186.52382.F4"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715040-00010"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00445.2004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3922-16.2017"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.057067"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.4.576"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04001-5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144030"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aau6324","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aau6324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T19:42:42Z","timestamp":1705347762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aau6324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":28,"journal-issue":{"issue":"6413","published-print":{"date-parts":[[2018,10,26]]}},"alternative-id":["10.1126\/science.aau6324"],"URL":"https:\/\/doi.org\/10.1126\/science.aau6324","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734297167.793552344","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.734297167.793552574","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.734297167.793563540","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}