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Treatment resulted in selective killing of the bacteria in vitro and in a mouse model. The target pathways were made sensitive to PptT inhibition by a second enzyme, phosphopantetheine hydrolase, whose activity opposes that of the transferase.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau8959\">eaau8959<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6426\" page=\"457\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aaw5224\">457<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau8959","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T19:09:20Z","timestamp":1548961760000},"source":"Crossref","is-referenced-by-count":75,"title":["Opposing reactions in coenzyme A metabolism sensitize\n                    <i>Mycobacterium tuberculosis<\/i>\n                    to enzyme inhibition"],"prefix":"10.1126","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-2106","authenticated-orcid":true,"given":"Elaine","family":"Ballinger","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-7824","authenticated-orcid":true,"given":"John","family":"Mosior","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, 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