{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:49:21Z","timestamp":1790628561454,"version":"4.1.0"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6452","funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["102942\/Z\/13\/A"],"award-info":[{"award-number":["102942\/Z\/13\/A"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kennel Club Charitable Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,8,2]]},"abstract":"<jats:title>It's a dog's life<\/jats:title>\n                  <jats:p>\n                    Canine transmissible venereal tumor is one of the few cancer lineages that is transferred among individuals through contact. It arose millennia ago and has been evolving independently from its hosts ever since. Baez-Ortega\n                    <jats:italic>et al.<\/jats:italic>\n                    looked at the phylogenetic history of the cancer and describe several distinctive mutational patterns (see the Perspective by Maley and Shibata). Most notably, both positive and negative selection show only weak or distant signals. This suggests that the main driver of the lineage's evolution is neutral genetic drift. Understanding the influence of drift may reshape how we think about long-term cancer evolution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aau9923\">eaau9923<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6452\" page=\"440\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aay2859\">440<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aau9923","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:05:53Z","timestamp":1564686353000},"source":"Crossref","is-referenced-by-count":70,"title":["Somatic evolution and global expansion of an ancient transmissible cancer lineage"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-4420","authenticated-orcid":true,"given":"Adrian","family":"Baez-Ortega","sequence":"first","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-4275","authenticated-orcid":true,"given":"Kevin","family":"Gori","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-5515","authenticated-orcid":true,"given":"Andrea","family":"Strakova","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Allum","sequence":"additional","affiliation":[{"name":"World Vets, Gig Harbor, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontine","family":"Bansse-Issa","sequence":"additional","affiliation":[{"name":"Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thinlay N.","family":"Bhutia","sequence":"additional","affiliation":[{"name":"Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-1807","authenticated-orcid":true,"given":"Jocelyn L.","family":"Bisson","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."},{"name":"Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin EH25 9RG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-650X","authenticated-orcid":true,"given":"Crist\u00f3bal","family":"Brice\u00f1o","sequence":"additional","affiliation":[{"name":"ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemio","family":"Castillo Domracheva","sequence":"additional","affiliation":[{"name":"Corozal Veterinary Hospital, University of Panam\u00e1, Panama City, Republic of Panama."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Corrigan","sequence":"additional","affiliation":[{"name":"St. George's University, True Blue, Grenada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh R.","family":"Cran","sequence":"additional","affiliation":[{"name":"The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane T.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Animal Medical Centre, Belize City, Belize."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-8941","authenticated-orcid":true,"given":"Eric","family":"Davis","sequence":"additional","affiliation":[{"name":"International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina F.","family":"de Castro","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Rio Preto (UNIRP), S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-2144","authenticated-orcid":true,"given":"Andrigo","family":"B. de Nardi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Veterinary Surgery, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"de Vos","sequence":"additional","affiliation":[{"name":"Ladybrand Animal Clinic, Ladybrand, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Delgadillo Keenan","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Sr. Dog\u2019s, Guadalajara, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-3057","authenticated-orcid":true,"given":"Edward M.","family":"Donelan","sequence":"additional","affiliation":[{"name":"Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-8131","authenticated-orcid":true,"given":"Adela R.","family":"Espinoza Huerta","sequence":"additional","affiliation":[{"name":"World Vets Latin America Veterinary Training Center, Granada, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibikunle A.","family":"Faramade","sequence":"additional","affiliation":[{"name":"National Veterinary Research Institute, Vom, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-9022","authenticated-orcid":true,"given":"Mohammed","family":"Fazil","sequence":"additional","affiliation":[{"name":"Animal Clinic, Mombasa, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Fotopoulou","sequence":"additional","affiliation":[{"name":"Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye N.","family":"Fruean","sequence":"additional","affiliation":[{"name":"Animal Protection Society of Samoa, Apia, Samoa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Gallardo-Arrieta","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Glebova","sequence":"additional","affiliation":[{"name":"Veterinary Clinic BIOCONTROL, Moscow, Russia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-0528","authenticated-orcid":true,"given":"Pagona G.","family":"Gouletsou","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo F.","family":"H\u00e4felin Manrique","sequence":"additional","affiliation":[{"name":"Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-2277","authenticated-orcid":true,"given":"Joaquim J. G. P.","family":"Henriques","sequence":"additional","affiliation":[{"name":"OnevetGroup, Hospital Veterin\u00e1rio Berna, Lisboa, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S.","family":"Horta","sequence":"additional","affiliation":[{"name":"Universidade Vila Velha, Vila Velha, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ignatenko","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Zoovetservis, Kiev, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghouba","family":"Kane","sequence":"additional","affiliation":[{"name":"\u00c9cole Inter-\u00e9tats des Sciences et M\u00e9decine V\u00e9t\u00e9rinaires de Dakar, Dakar, Senegal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"King","sequence":"additional","affiliation":[{"name":"World Vets, Gig Harbor, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Koenig","sequence":"additional","affiliation":[{"name":"World Vets, Gig Harbor, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Krupa","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Kruzeniski","sequence":"additional","affiliation":[{"name":"World Vets Latin America Veterinary Training Center, Granada, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lanza-Perea","sequence":"additional","affiliation":[{"name":"St. George's University, True Blue, Grenada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihran","family":"Lazyan","sequence":"additional","affiliation":[{"name":"Vetexpert Veterinary Group, Yerevan, Armenia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-3397","authenticated-orcid":true,"given":"Adriana M.","family":"Lopez Quintana","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Lopez Quintana, Maldonado, Uruguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Losfelt","sequence":"additional","affiliation":[{"name":"Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-0307","authenticated-orcid":true,"given":"Sim\u00f3n","family":"Mart\u00ednez Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-3960","authenticated-orcid":true,"given":"Mayra F.","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Universidad de las Am\u00e9ricas, Quito, Ecuador."},{"name":"Cancer Development and Innate Immune Evasion Lab, Champalimaud Center for the Unknown, Lisbon, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Meyer","sequence":"additional","affiliation":[{"name":"Touray &amp; Meyer Vet Clinic, Serrekunda, The Gambia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Migneco","sequence":"additional","affiliation":[{"name":"Hillside Animal Hospital, St. Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Nakanwagi","sequence":"additional","affiliation":[{"name":"The Kampala Veterinary Surgery, Kampala, Uganda."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karter B.","family":"Neal","sequence":"additional","affiliation":[{"name":"Asavet Veterinary Charities, Tucson, AZ, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winifred","family":"Neunzig","sequence":"additional","affiliation":[{"name":"World Vets, Gig Harbor, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-4935","authenticated-orcid":true,"given":"M\u00e1ire","family":"N\u00ed Leathlobhair","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally J.","family":"Nixon","sequence":"additional","affiliation":[{"name":"Vets Beyond Borders, Bylakuppe, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-8023","authenticated-orcid":true,"given":"Antonio","family":"Ortega-Pacheco","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3217-8941","authenticated-orcid":true,"given":"Francisco","family":"Pedraza-Ordo\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Veterinaria, Universidad de Caldas, Manizales, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Polak","sequence":"additional","affiliation":[{"name":"Four Paws International, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-3329","authenticated-orcid":true,"given":"Ruth J.","family":"Pye","sequence":"additional","affiliation":[{"name":"Vets Beyond Borders, The Rocks, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Reece","sequence":"additional","affiliation":[{"name":"Help in Suffering, Jaipur, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Rojas Gutierrez","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Dr Jos\u00e9 Rojas, Los Andes, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleema","family":"Sadia","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3828-9818","authenticated-orcid":true,"given":"Sheila K.","family":"Schmeling","sequence":"additional","affiliation":[{"name":"Corozal Veterinary Clinic, Corozal Town, Belize."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Shamanova","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Vetmaster, Ramenskoye, Russia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Sherlock","sequence":"additional","affiliation":[{"name":"Vets Beyond Borders, The Rocks, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-9199","authenticated-orcid":true,"given":"Maximilian","family":"Stammnitz","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey E.","family":"Steenland-Smit","sequence":"additional","affiliation":[{"name":"Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Svitich","sequence":"additional","affiliation":[{"name":"State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester J.","family":"Tapia Mart\u00ednez","sequence":"additional","affiliation":[{"name":"World Vets Latin America Veterinary Training Center, Granada, Nicaragua."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Thoya Ngoka","sequence":"additional","affiliation":[{"name":"Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0019-2404","authenticated-orcid":true,"given":"Cristian G.","family":"Torres","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Tudor","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam G.","family":"van der Wel","sequence":"additional","affiliation":[{"name":"Animal Anti Cruelty League, Port Elizabeth, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan A.","family":"Vi\u0163\u0103laru","sequence":"additional","affiliation":[{"name":"Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-3381","authenticated-orcid":true,"given":"Sevil A.","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Walkinton","sequence":"additional","affiliation":[{"name":"Vets Beyond Borders, The Rocks, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-9856","authenticated-orcid":true,"given":"Jinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro S.","family":"Wehrle-Martinez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A. E.","family":"Widdowson","sequence":"additional","affiliation":[{"name":"Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-153X","authenticated-orcid":true,"given":"Michael R.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Hinxton, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-4515","authenticated-orcid":true,"given":"Ludmil B.","family":"Alexandrov","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-4416","authenticated-orcid":true,"given":"I\u00f1igo","family":"Martincorena","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Hinxton, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-8907","authenticated-orcid":true,"given":"Elizabeth P.","family":"Murchison","sequence":"additional","affiliation":[{"name":"Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005904"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2015.03.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"D. P. Blaine A Domestic Treatise on the Diseases of Horses and Dogs (T. Boosey London 1810).","DOI":"10.5962\/bhl.title.27833"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0168-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07943"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.018"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3441"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4776"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.14552"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247167"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.190314.115"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"K. C. Gori A. Baez-Ortega sigfit: Flexible Bayesian inference of mutational signatures. bioRxiv 372896 [Preprint]. 10 July 2018. https:\/\/doi.org\/10.1101\/372896","DOI":"10.1101\/372896"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1075"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08658"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.042"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"L. B. Alexandrov et al . The repertoire of mutational signatures in human cancer. bioRxiv 322859 [Preprint]. (15 May 2018). https:\/\/doi.org\/10.1101\/322859","DOI":"10.1101\/322859"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20544"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/B700017K"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.057"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17676"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11383"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.050"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01358-x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120213-092015"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.4.1054"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx731"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3987"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006506"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(64)90047-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1990.tb00887.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12377"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.051"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-009-0809-1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24284"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3036"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0974-4"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss075"},{"key":"e_1_3_2_44_2","unstructured":"A. Baez-Ortega Somatic evolution and global expansion of an ancient transmissible cancer lineage University of Cambridge Repository (2019); 10.17863\/CAM.24962"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091172"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094607.109"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.20"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3469"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.04.019"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16082"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v076.i01"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi103"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.12.008"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx082"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/ietfec\/e91-a.1.39"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-9-13"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7563.1"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz031"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/148.3.929"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02722-1"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14248"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20145216"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7557"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7041"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.017"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1299"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aau9923","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aau9923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T17:33:12Z","timestamp":1705339992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aau9923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":69,"journal-issue":{"issue":"6452","published-print":{"date-parts":[[2019,8,2]]}},"alternative-id":["10.1126\/science.aau9923"],"URL":"https:\/\/doi.org\/10.1126\/science.aau9923","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736330215.793563532","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,2]]},"article-number":"eaau9923"}}