{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:00:13Z","timestamp":1793070013414,"version":"4.5.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6433","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD075795"],"award-info":[{"award-number":["HD075795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD076412"],"award-info":[{"award-number":["HD076412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OD011092"],"award-info":[{"award-number":["OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD092084"],"award-info":[{"award-number":["HD092084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,3,22]]},"abstract":"<jats:title>Preserving male fertility<\/jats:title>\n                  <jats:p>\n                    Before chemotherapy or radiation treatment, sperm from adult men can be cryopreserved for future use. However, this is not possible for prepubertal boys. Fayomi\n                    <jats:italic>et al.<\/jats:italic>\n                    grafted cryopreserved testicular tissue from castrated pubertal rhesus macaques, placing each animal's own testis sections under the skin of the back or scrotum (see the Perspective by Neuhaus and Schlatt). Grafts grew, produced testosterone, and were able to generate sperm that could fertilize oocytes, in one case resulting in a successful pregnancy. The results hold promise for preserving human fertility, for example, after childhood cancer treatments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6433\" page=\"1314\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aav2914\">1314<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6433\" page=\"1283\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aaw6927\">1283<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aav2914","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T19:15:16Z","timestamp":1553195716000},"page":"1314-1319","source":"Crossref","is-referenced-by-count":322,"title":["Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring"],"prefix":"10.1126","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-9635","authenticated-orcid":true,"given":"Adetunji P.","family":"Fayomi","sequence":"first","affiliation":[{"name":"Molecular Genetics and Developmental Biology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA."},{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA."},{"name":"Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, 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