{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:18:29Z","timestamp":1791875909116,"version":"4.3.4"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6467","funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["130823"],"award-info":[{"award-number":["130823"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["146133"],"award-info":[{"award-number":["146133"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01ES0901"],"award-info":[{"award-number":["FKZ 01ES0901"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01ES0802"],"award-info":[{"award-number":["FKZ 01ES0802"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interdisciplinary Centre for Clinical Research, Universit\u00e4t of W\u00fcrzburg, Germany","award":["E-354"],"award-info":[{"award-number":["E-354"]}]},{"name":"Interdisciplinary Centre for Clinical Research","award":["E-32"],"award-info":[{"award-number":["E-32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Peptide mimicry breaks the heart<\/jats:title>\n                  <jats:p>\n                    Myocarditis, a prolonged chronic inflammation of heart muscle, can eventually progress to inflammatory cardiomyopathy, a serious condition associated with heart failure. Activated T helper (T\n                    <jats:sub>H<\/jats:sub>\n                    ) cells that recognize myosin heavy chain 6\u2013derived peptides are thought to play a central role in this pathogenesis. Using a mouse model of myocarditis, Gil-Cruz\n                    <jats:italic>et al.<\/jats:italic>\n                    found that cardiac myosin\u2013reactive T\n                    <jats:sub>H<\/jats:sub>\n                    cells are initially primed by myosin-peptide mimics derived from commensal\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    species in the gut (see the Perspective by Epelman). Unlike heathy controls, human myocarditis patients also showed detectable immune reactivity to both\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    and cardiac myosin antigens. Treatment with antibiotics dampened inflammatory responses and prevented lethal heart disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6467\" page=\"881\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aav3487\">881<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6467\" page=\"806\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aaz4400\">806<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aav3487","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:06:31Z","timestamp":1573758391000},"page":"881-886","source":"Crossref","is-referenced-by-count":260,"title":["Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-6503","authenticated-orcid":true,"given":"Cristina","family":"Gil-Cruz","sequence":"first","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Perez-Shibayama","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"De Martin","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ronchi","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories, Department of Biomedical Research, Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, University of Berne, Berne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"van der Borght","sequence":"additional","affiliation":[{"name":"VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka","family":"Niederer","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Onder","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9011-5319","authenticated-orcid":true,"given":"Mechthild","family":"L\u00fctge","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-5777","authenticated-orcid":true,"given":"Mario","family":"Novkovic","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Nindl","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9582-2725","authenticated-orcid":true,"given":"Gustavo","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany."},{"name":"Comprehensive Heart Failure Center, University Hospital of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Arnoldini","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health, ETH, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-1145","authenticated-orcid":true,"given":"Emma M.C.","family":"Slack","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health, ETH, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-4875","authenticated-orcid":true,"given":"Val\u00e9rie","family":"Boivin-Jahns","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center, University Hospital of W\u00fcrzburg, W\u00fcrzburg, Germany."},{"name":"Institute of Pharmacology and Toxicology, University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-8191","authenticated-orcid":true,"given":"Roland","family":"Jahns","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center, University Hospital of W\u00fcrzburg, W\u00fcrzburg, Germany."},{"name":"Interdisciplinary Bank of Biomaterials and Data W\u00fcrzburg (IBDW), University Hospital of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Wyss","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Mooser","sequence":"additional","affiliation":[{"name":"Maurice M\u00fcller Laboratories, Department of Biomedical Research, Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin Inselspital, University of Berne, Berne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha 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