{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:14:21Z","timestamp":1791490461538,"version":"4.3.4"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6455","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WTSI - IF"],"award-info":[{"award-number":["WTSI - IF"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0600718"],"award-info":[{"award-number":["G0600718"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,8,23]]},"abstract":"<jats:title>Ebb and flow of parasite populations<\/jats:title>\n          <jats:p>\n            The population genetics of the malaria parasite\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwa\n            <jats:italic>et al.<\/jats:italic>\n            of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population of\n            <jats:italic>P. falciparum<\/jats:italic>\n            , which may be indicative of coexistence with another malaria parasite,\n            <jats:italic>P. vivax.<\/jats:italic>\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6455\" page=\"813\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aav5427\">813<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6455\" page=\"752\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aay0988\">752<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aav5427","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T21:36:26Z","timestamp":1567546586000},"page":"813-816","source":"Crossref","is-referenced-by-count":161,"title":["Major subpopulations of\n            <i>Plasmodium falciparum<\/i>\n            in sub-Saharan Africa"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-3601","authenticated-orcid":true,"given":"Alfred","family":"Amambua-Ngwa","sequence":"first","affiliation":[{"name":"Medical Research Council Unit The Gambia at LSHTM, Banjul, The Gambia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-0506","authenticated-orcid":true,"given":"Lucas","family":"Amenga-Etego","sequence":"additional","affiliation":[{"name":"West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), 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