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There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core \u03b1 subunit is sufficient for voltage sensing and ion conductance, but function is modulated by \u03b2 subunits and by natural toxins that can either act as pore blockers or gating modifiers (see the Perspective by Chowdhury and Chanda). Shen\n            <jats:italic>et al.<\/jats:italic>\n            present the structures of Na\n            <jats:sub>v<\/jats:sub>\n            1.7 in complex with both \u03b21 and \u03b22 subunits and with animal toxins. Pan\n            <jats:italic>et al.<\/jats:italic>\n            present the structure of Na\n            <jats:sub>v<\/jats:sub>\n            1.2 bound to \u03b22 and a toxic peptide, the \u00b5-conotoxin KIIIA. The structure shows why KIIIA is specific for Na\n            <jats:sub>v<\/jats:sub>\n            1.2. These and other recently determined Na\n            <jats:sub>v<\/jats:sub>\n            structures provide a framework for targeted drug development.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6433\" page=\"1303\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aaw2493\">1303<\/jats:related-article>\n            , p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6433\" page=\"1309\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aaw2999\">1309<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6433\" page=\"1278\" related-article-type=\"in-this-issue\" vol=\"363\" xlink:href=\"10.1126\/science.aaw8645\">1278<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaw2493","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:17:01Z","timestamp":1550189821000},"page":"1303-1308","source":"Crossref","is-referenced-by-count":432,"title":["Structures of human Na\n            <sub>v<\/sub>\n            1.7 channel in complex with auxiliary subunits and animal toxins"],"prefix":"10.1126","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-5393","authenticated-orcid":true,"given":"Huaizong","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China."},{"name":"Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China."},{"name":"Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, 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