{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:12Z","timestamp":1791925272449,"version":"4.3.4"},"reference-count":37,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6449","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,7,12]]},"abstract":"<jats:title>Placenta formation and fetal demise<\/jats:title>\n          <jats:p>\n            A critical step of placental development is the fusion of trophoblast cells into a multi-nucleated syncytiotrophoblast layer. Trophoblast fusion is mediated by syncytins, encoded by endogenous retrovirus\u2013derived envelope glycoproteins. Buchrieser\n            <jats:italic>et al.<\/jats:italic>\n            report that interferon-induced transmembrane (IFITM) proteins inhibit syncytin-mediated syncytiotrophoblast formation, restricting placental development and triggering fetal demise (see the Perspective by Kellam and Weiss). The results provide a molecular explanation for the placental dysfunctions observed in interferon-mediated disorders such as intrauterine growth retardation, TORCH (toxoplasmosis, other, rubella, cytomegalovirus, and herpes) infections, and some forms of preeclampsia.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6449\" page=\"176\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aaw7733\">176<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6449\" page=\"118\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aay2054\">118<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaw7733","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T16:55:53Z","timestamp":1636131353000},"page":"176-180","source":"Crossref","is-referenced-by-count":172,"title":["IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-7577","authenticated-orcid":true,"given":"Julian","family":"Buchrieser","sequence":"first","affiliation":[{"name":"Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France."},{"name":"CNRS-UMR3569, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-4875","authenticated-orcid":true,"given":"S\u00e9verine A.","family":"Degrelle","sequence":"additional","affiliation":[{"name":"INSERM, UMR-S1139, Facult\u00e9 de Pharmacie de Paris, Paris, France."},{"name":"Universit\u00e9 Paris 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