{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:32:31Z","timestamp":1790137951762,"version":"4.0.1"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6457","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,9,6]]},"abstract":"An antibody is not the antidote<\/jats:title>\n \n An HIV therapeutic that would give long-term remission without sustained antiretroviral therapy (ART) is a long-term goal. Byrareddy\n et al.<\/jats:italic>\n [\n Science<\/jats:italic>\n 354<\/jats:bold>\n , 197 (2016)] reported that treating simian immunodeficiency virus (SIV)\u2013positive macaques with an antibody against integrin \u03b1\n 4<\/jats:sub>\n \u03b2\n 7<\/jats:sub>\n during and after ART results in sustained virologic control after stopping all treatment. Three studies in this issue question the reproducibility of that result. Di Mascio\n et al.<\/jats:italic>\n sequenced the virus used in the 2016 study and found that it was a variant with a stop codon in the\n nef<\/jats:italic>\n gene rather than a wild-type virus. Abbink\n et al.<\/jats:italic>\n used the same antibody for \u03b1\n 4<\/jats:sub>\n \u03b2\n 7<\/jats:sub>\n as before but tested control of a more commonly used pathogenic virus. Iwamato\n et al.<\/jats:italic>\n used the same\n nef<\/jats:italic>\n -stop virus as in the earlier paper but combined the antibody against the integrin with an antibody against the SIV envelope glycoprotein, which also blocks viral binding of the integrin. None of these three new studies found that treating with the antibody had any effect on virologic control after stopping ART treatment.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 1025<\/jats:related-article>\n , p.\n 1029<\/jats:related-article>\n , p.\n 1033<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.aaw7765","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T23:05:26Z","timestamp":1567724726000},"page":"1033-1036","source":"Crossref","is-referenced-by-count":36,"title":["Blocking \u03b1\n 4<\/sub>\n \u03b2\n 7<\/sub>\n integrin binding to SIV does not improve virologic control"],"prefix":"10.1126","volume":"365","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-1500","authenticated-orcid":true,"given":"Nami","family":"Iwamoto","sequence":"first","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7123-4902","authenticated-orcid":true,"given":"Rosemarie D.","family":"Mason","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaimei","family":"Song","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-6560","authenticated-orcid":true,"given":"Jason","family":"Gorman","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-1203","authenticated-orcid":true,"given":"Hugh C.","family":"Welles","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-4267","authenticated-orcid":true,"given":"James","family":"Arthos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-8997","authenticated-orcid":true,"given":"Claudia","family":"Cicala","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Min","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-198X","authenticated-orcid":true,"given":"Hannah A. D.","family":"King","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-115X","authenticated-orcid":true,"given":"Aaron J.","family":"Belli","sequence":"additional","affiliation":[{"name":"MassBiologics, University of Massachusetts Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-6500","authenticated-orcid":true,"given":"Keith A.","family":"Reimann","sequence":"additional","affiliation":[{"name":"MassBiologics, University of Massachusetts Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-6495","authenticated-orcid":true,"given":"Kathryn E.","family":"Foulds","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-232X","authenticated-orcid":true,"given":"Peter D.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-0268","authenticated-orcid":true,"given":"Jeffrey D.","family":"Lifson","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-1151","authenticated-orcid":true,"given":"Brandon F.","family":"Keele","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-7040","authenticated-orcid":true,"given":"Mario","family":"Roederer","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1333"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.738-749.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1996.12.1691"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.03.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608243"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14411"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18929"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1276"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.4049\/jimmunol.133.4.1857","article-title":"Lymphocyte activation antigens. 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