{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:51:35Z","timestamp":1792439495617,"version":"4.5.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6487","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50 MH096890"],"award-info":[{"award-number":["P50 MH096890"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH108842"],"award-info":[{"award-number":["R01 MH108842"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DP1 DA042078"],"award-info":[{"award-number":["DP1 DA042078"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA044767"],"award-info":[{"award-number":["R21DA044767"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA 025983"],"award-info":[{"award-number":["DA 025983"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA037257"],"award-info":[{"award-number":["R01 DA037257"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21 DA044486"],"award-info":[{"award-number":["R21 DA044486"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F99 NS108543"],"award-info":[{"award-number":["F99 NS108543"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA042111"],"award-info":[{"award-number":["DA042111"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012643","name":"Edward Mallinckrodt, Jr. Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000879","name":"Alfred P. Sloan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000882","name":"Brain Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000882","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MQ Mental Health Charity","award":["MQ15FIP100011"],"award-info":[{"award-number":["MQ15FIP100011"]}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31 DA045428"],"award-info":[{"award-number":["F31 DA045428"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,4,10]]},"abstract":"<jats:title>More than a normal neurotransmitter<\/jats:title>\n                  <jats:p>\n                    The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack\n                    <jats:italic>et al.<\/jats:italic>\n                    found that, with cocaine exposure, there is an intracellular accumulation of dopamine in neurons of a brain region called the ventral tegmental area (see the Perspective by Girault). Dopamine associates with chromatin to initiate a previously unknown form of epigenetic regulation called dopaminylation. This modification has an impact on ventral tegmental area function and, consequently, on dopaminergic action potentials. The result is aberrant dopamine signaling in the ventral striatum during periods of drug seeking.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6487\" page=\"197\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.aaw8806\">197<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6487\" page=\"134\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.abb3533\">134<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaw8806","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T19:06:11Z","timestamp":1586459171000},"page":"197-201","source":"Crossref","is-referenced-by-count":252,"title":["Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking"],"prefix":"10.1126","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5286","authenticated-orcid":true,"given":"Ashley E.","family":"Lepack","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-777X","authenticated-orcid":true,"given":"Craig T.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, State University of New York at Buffalo, Buffalo, NY 14214, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-3927","authenticated-orcid":true,"given":"Andrew F.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha L.","family":"Fulton","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-344X","authenticated-orcid":true,"given":"Ping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna A.","family":"Farrelly","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-6234","authenticated-orcid":true,"given":"Alexander C. W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-6502","authenticated-orcid":true,"given":"Aarthi","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4442-9015","authenticated-orcid":true,"given":"Yang","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-0398","authenticated-orcid":true,"given":"Ryan M.","family":"Bastle","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-1319","authenticated-orcid":true,"given":"Jennifer A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, State University of New York at Buffalo, Buffalo, NY 14214, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarup","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, State University of New York at Buffalo, Buffalo, NY 14214, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-4990","authenticated-orcid":true,"given":"Henrik","family":"Molina","sequence":"additional","affiliation":[{"name":"Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-2851","authenticated-orcid":true,"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-9596","authenticated-orcid":true,"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4723-0623","authenticated-orcid":true,"given":"Erin S.","family":"Calipari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-9236","authenticated-orcid":true,"given":"David M.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, State University of New York at Buffalo, Buffalo, NY 14214, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-7781","authenticated-orcid":true,"given":"Ian","family":"Maze","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1024-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01014-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35084134"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06995"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00742.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05893.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012047"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.07.062"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0525-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.028"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5387.298"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.1.1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2012-0066"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.07.014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890010508"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09202"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA03660C"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq636"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1470-11.2011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019136"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5671-10.2011"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13877"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.03.001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12381"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.136"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0322-8_10"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aaw8806","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aaw8806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T19:25:07Z","timestamp":1705346707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aaw8806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":30,"journal-issue":{"issue":"6487","published-print":{"date-parts":[[2020,4,10]]}},"alternative-id":["10.1126\/science.aaw8806"],"URL":"https:\/\/doi.org\/10.1126\/science.aaw8806","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737710881.793585458","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]}}}