{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:46:32Z","timestamp":1790847992522,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6505","funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["077926"],"award-info":[{"award-number":["077926"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02 NeuroCoG"],"award-info":[{"award-number":["ANR-15-IDEX-02 NeuroCoG"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Network of centers of excellence in neurodegeneration COEN"],"award-info":[{"award-number":["Network of centers of excellence in neurodegeneration COEN"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","award":["Programme transversal veillissement - AGEMED"],"award-info":[{"award-number":["Programme transversal veillissement - AGEMED"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["Equipe FRM"],"award-info":[{"award-number":["Equipe FRM"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"publisher","award":["CIFRE"],"award-info":[{"award-number":["CIFRE"]}],"id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006424","name":"F\u00e9d\u00e9ration pour la Recherche sur le Cerveau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["Post-doctoral fellowship"],"award-info":[{"award-number":["Post-doctoral fellowship"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:title>Neural progenitors disrupted<\/jats:title>\n                  <jats:p>\n                    Symptoms of Huntington's disease (HD) manifest in adulthood despite the aberrant protein being present much earlier in persons carrying the disease-causing mutation. Barnat\n                    <jats:italic>et al.<\/jats:italic>\n                    studied the cellular effects of the HD mutation on human and mouse fetal brain development (see the Perspective by DiFiglia). The authors found that neural progenitor cells at the brain's ventricular zone reach out to both the apical and basal surfaces of the neuroepithelial wall, and their cellular nuclei shuttle back and forth as the cell cycle progresses. With the aberrant protein, these epithelial junctions are disrupted, epithelial polarity is disturbed, and the cell cycle favors premature neuronal differentiation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6505\" page=\"787\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.aax3338\">787<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6505\" page=\"771\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abd6215\">771<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aax3338","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:14:47Z","timestamp":1594926887000},"page":"787-793","source":"Crossref","is-referenced-by-count":335,"title":["Huntington\u2019s disease alters human neurodevelopment"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4653-3254","authenticated-orcid":true,"given":"Monia","family":"Barnat","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-8439","authenticated-orcid":true,"given":"Mariacristina","family":"Capizzi","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-519X","authenticated-orcid":true,"given":"Susana","family":"Boluda","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Raymond Escourolle, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4718-9616","authenticated-orcid":true,"given":"Doris","family":"Wennagel","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-7361","authenticated-orcid":true,"given":"Radhia","family":"Kacher","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-6638","authenticated-orcid":true,"given":"Rayane","family":"Kassem","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-033X","authenticated-orcid":true,"given":"Sophie","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-6196","authenticated-orcid":true,"given":"Fabienne","family":"Agasse","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-5031","authenticated-orcid":true,"given":"Barbara Y.","family":"Braz","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-4425","authenticated-orcid":true,"given":"Jeh-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-1592","authenticated-orcid":true,"given":"Julien","family":"Ighil","sequence":"additional","affiliation":[{"name":"AP-HP, Sorbonne University, Service de Gyn\u00e9cologie Obst\u00e9trique, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-4686","authenticated-orcid":true,"given":"Aude","family":"Tessier","sequence":"additional","affiliation":[{"name":"AP-HP, Unit\u00e9 d\u2019Embryofoetopathologie, Necker Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-3343","authenticated-orcid":true,"given":"Scott O.","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-4810","authenticated-orcid":true,"given":"Charles","family":"Duyckaerts","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Raymond Escourolle, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-4525","authenticated-orcid":true,"given":"Marc","family":"Dommergues","sequence":"additional","affiliation":[{"name":"AP-HP, Sorbonne University, Service de Gyn\u00e9cologie Obst\u00e9trique, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-7104","authenticated-orcid":true,"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute, APHP, INSERM U1127, CNRS UMR7225, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-1046","authenticated-orcid":true,"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institut Neurosciences, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-155"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1385\/MN:28:3:259"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.027"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4699-13.2014"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.035"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0715-14.2014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.09.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603871113"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182648b65"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq280"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69411"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.013"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603020113"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.11.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4532"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715865115"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00384"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00473"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.6.633"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-5-28"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2680-0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.117"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3080"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201546"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002142"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv208"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101011-155801"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.192997"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.033"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.81"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1155"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.069294"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00070"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102211"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96765"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"e1908","DOI":"10.1212\/WNL.0000000000009364","article-title":"Abnormal development of cerebellar-striatal circuitry in Huntington disease","volume":"94","author":"Tereshchenko A. V.","year":"2020","unstructured":"A. V. Tereshchenko, J. L. Schultz, J. E. Bruss, V. A. Magnotta, E. A. Epping, P. C. Nopoulos, Abnormal development of cerebellar-striatal circuitry in Huntington disease. Neurology 94, e1908\u2013e1915 (2020). doi:32265233","journal-title":"Neurology"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aax3338","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aax3338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T19:12:47Z","timestamp":1705345967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aax3338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":40,"journal-issue":{"issue":"6505","published-print":{"date-parts":[[2020,8,14]]}},"alternative-id":["10.1126\/science.aax3338"],"URL":"https:\/\/doi.org\/10.1126\/science.aax3338","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738340614.793578862","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.738340614.793578997","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.738340614.793576873","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.738340614.793582970","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]}}}