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A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple HIV strains (see the Perspective by Agazio and Torres). Steichen\n                    <jats:italic>et al.<\/jats:italic>\n                    report a strategy in which the first vaccine shot can lead to immune responses that generate desired bnAbs. By combining knowledge of human antibody repertoires and structure to guide design, they validated candidate immunogens through functional preclinical testing. Saunders\n                    <jats:italic>et al.<\/jats:italic>\n                    designed immunogens with differences in binding strength for bnAb precursors, which enabled selection of rare mutations after immunization. The immunogens promoted bnAb precursor maturation in humanized mice and macaques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aax4380\">eaax4380<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aay7199\">eaay7199<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6470\" page=\"1197\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aaz8647\">1197<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aax4380","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T19:05:25Z","timestamp":1572548725000},"source":"Crossref","is-referenced-by-count":289,"title":["A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-3251","authenticated-orcid":true,"given":"Jon M.","family":"Steichen","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Consortium for HIV\/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-7974","authenticated-orcid":true,"given":"Ying-Cing","family":"Lin","sequence":"additional","affiliation":[{"name":"The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-3927","authenticated-orcid":true,"given":"Colin","family":"Havenar-Daughton","sequence":"additional","affiliation":[{"name":"Consortium for HIV\/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-4324","authenticated-orcid":true,"given":"Simone","family":"Pecetta","sequence":"additional","affiliation":[{"name":"The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Ozorowski","sequence":"additional","affiliation":[{"name":"IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Consortium for HIV\/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0135-5263","authenticated-orcid":true,"given":"Jordan 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