{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:08:21Z","timestamp":1792098501337,"version":"4.4.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6458","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81788101"],"award-info":[{"award-number":["81788101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>RNA modification meets immune metabolism<\/jats:title>\n                  <jats:p>\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) RNA modification regulates various cellular functions. Liu\n                    <jats:italic>et al.<\/jats:italic>\n                    found that host cells impair RNA m\n                    <jats:sup>6<\/jats:sup>\n                    A demethylase activity after viral infection, leading to increased m\n                    <jats:sup>6<\/jats:sup>\n                    A and reduced stability of \u03b1-ketoglutarate dehydrogenase (OGDH) mRNA. As a result, reduced OGDH decreases the generation of itaconate, thereby inhibiting viral replication. The authors explore the function of OGDH and itaconate in viral infection, provide insights into m\n                    <jats:sup>6<\/jats:sup>\n                    A RNA modification and metabolic reprogramming in modulating virus-host interaction, and suggest potential therapeutic targets for the control of viral infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6458\" page=\"1171\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126\/science.aax4468\">1171<\/jats:related-article>\n                  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